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DeLalio LJ, Stocker SD. Impact of anesthesia and sex on sympathetic efferent and hemodynamic responses to renal chemo- and mechanosensitive stimuli. J Neurophysiol. 2021;126(2):668-679doi: 10.1152/jn.00277.2021.
DeLalio, L. J., & Stocker, S. D. (2021). Impact of anesthesia and sex on sympathetic efferent and hemodynamic responses to renal chemo- and mechanosensitive stimuli. Journal of neurophysiology, 126(2), 668-679. https://doi.org/10.1152/jn.00277.2021
DeLalio, Leon J, and Stocker, Sean D. "Impact of anesthesia and sex on sympathetic efferent and hemodynamic responses to renal chemo- and mechanosensitive stimuli." Journal of neurophysiology vol. 126,2 (2021): 668-679. doi: https://doi.org/10.1152/jn.00277.2021
DeLalio LJ, Stocker SD. Impact of anesthesia and sex on sympathetic efferent and hemodynamic responses to renal chemo- and mechanosensitive stimuli. J Neurophysiol. 2021 Aug 01;126(2):668-679. doi: 10.1152/jn.00277.2021. Epub 2021 Jul 14. PMID: 34259043; PMCID: PMC8409959.
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J Neurophysiol. 2021 Aug 01;126(2):668-679. doi: 10.1152/jn.00277.2021. Epub 2021 Jul 14.

Impact of anesthesia and sex on sympathetic efferent and hemodynamic responses to renal chemo- and mechanosensitive stimuli.

Journal of neurophysiology

Leon J DeLalio, Sean D Stocker

Affiliations

  1. Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

PMID: 34259043 PMCID: PMC8409959 DOI: 10.1152/jn.00277.2021

Abstract

Activation of renal sensory nerves by chemo- and mechanosensitive stimuli produces changes in efferent sympathetic nerve activity (SNA) and arterial blood pressure (ABP). Anesthesia and sex influence autonomic function and cardiovascular hemodynamics, but it is unclear to what extent anesthesia and sex impact SNA and ABP responses to renal sensory stimuli. We measured renal, splanchnic, and lumbar SNA and ABP in male and female Sprague-Dawley rats during contralateral renal infusion of capsaicin and bradykinin or during elevation in renal pelvic pressure. Responses were evaluated with a decerebrate preparation or Inactin, urethane, or isoflurane anesthesia. Intrarenal arterial infusion of capsaicin (0.1-30.0 μM) increased renal SNA, splanchnic SNA, or ABP but decreased lumbar SNA in the Inactin group. Intrarenal arterial infusion of bradykinin (0.1-30.0 μM) increased renal SNA, splanchnic SNA, and ABP but decreased lumbar SNA in the Inactin group. Elevated renal pelvic pressure (0-20 mmHg, 30 s) significantly increased renal SNA and splanchnic SNA but not lumbar SNA in the Inactin group. In marked contrast, SNA and ABP responses to every renal stimulus were severely blunted in the urethane and decerebrate groups and absent in the isoflurane group. In the Inactin group, the magnitude of SNA responses to chemo- and mechanosensory stimuli were not different between male and female rats. Thus, chemo- and mechanosensitive stimuli produce differential changes in renal, splanchnic, and lumbar SNA. Experimentally, future investigations should consider Inactin anesthesia to examine sympathetic and hemodynamic responses to renal sensory stimuli.

Keywords: anesthesia; chemosensory; mechanosensory; renal nerves; renal reflex

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