Display options
Cite
Høgestøl EA, Ghezzo S, Nygaard GO, et al. Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study. Mult Scler. 2021;13524585211030212doi: 10.1177/13524585211030212.
Høgestøl, E. A., Ghezzo, S., Nygaard, G. O., Espeseth, T., Sowa, P., Beyer, M. K., Harbo, H. F., Westlye, L. T., Hulst, H. E., & Alnæs, D. (2021). Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study. Multiple sclerosis (Houndmills, Basingstoke, England), 13524585211030212. https://doi.org/10.1177/13524585211030212
Høgestøl, Einar August, et al. "Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study." Multiple sclerosis (Houndmills, Basingstoke, England) vol. (2021): 13524585211030212. doi: https://doi.org/10.1177/13524585211030212
Høgestøl EA, Ghezzo S, Nygaard GO, Espeseth T, Sowa P, Beyer MK, Harbo HF, Westlye LT, Hulst HE, Alnæs D. Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study. Mult Scler. 2021 Jul 14;13524585211030212. doi: 10.1177/13524585211030212. Epub 2021 Jul 14. PMID: 34259578.
Copy Download .nbib Format: NLM
Share it on

Mult Scler. 2021 Jul 14;13524585211030212. doi: 10.1177/13524585211030212. Epub 2021 Jul 14.

Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study.

Multiple sclerosis (Houndmills, Basingstoke, England)

Einar August Høgestøl, Samuele Ghezzo, Gro Owren Nygaard, Thomas Espeseth, Piotr Sowa, Mona K Beyer, Hanne Flinstad Harbo, Lars T Westlye, Hanneke E Hulst, Dag Alnæs

Affiliations

  1. "Department of Neurology, Neuroscience Research Unit, Multiple Sclerosis Research Group University of Oslo & Oslo University Hospital; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  2. NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway/Department of Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  3. Department of Neurology, Neuroscience Research Unit, Multiple Sclerosis Research Group University of Oslo & Oslo University Hospital, Oslo, Norway.
  4. Department of Psychology, University of Oslo, Oslo, Norway; Bjørknes College, Oslo, Norway.
  5. Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
  6. Institute of Clinical Medicine, University of Oslo, Oslo, Norway/Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
  7. NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway/Department of Psychology, University of Oslo, Oslo, Norway/KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.
  8. Department of Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands/Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.
  9. NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Bjørknes College, Oslo, Norway.

PMID: 34259578 DOI: 10.1177/13524585211030212

Abstract

BACKGROUND: Brain functional connectivity (FC) in multiple sclerosis (MS) is abnormal compared to healthy controls (HCs). More longitudinal studies in MS are needed to evaluate whether FC stability is clinically relevant.

OBJECTIVE: To compare functional magnetic resonance imaging (fMRI)-based FC between MS and HC, and to determine the relationship between longitudinal FC changes and structural brain damage, cognitive performance and physical disability.

METHODS: T1-weighted MPRAGE and resting-state fMRI (1.5T) were acquired from 70 relapsing-remitting MS patients and 94 matched HC at baseline (mean months since diagnosis 14.0 ± 11) and from 60 MS patients after 5 years. Independent component analysis and network modelling were used to measure longitudinal FC stability and cross-sectional comparisons with HC. Linear mixed models, adjusted for age and sex, were used to calculate correlations.

RESULTS: At baseline, patients with MS showed FC abnormalities both within networks and in single connections compared to HC. Longitudinal analyses revealed functional stability and no significant relationships with clinical disability, cognitive performance, lesion or brain volume.

CONCLUSION: FC abnormalities occur already at the first decade of MS, yet we found no relevant clinical correlations for these network deviations. Future large-scale longitudinal fMRI studies across a range of MS subtypes and outcomes are required.

Keywords: Multiple sclerosis; cohort studies; connectome; functional neuroimaging; longitudinal studies; neuroimaging; neuropsychological tests

Publication Types