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Caballero-García J, Jiménez-Martínez R, Giol-Álvarez AM, et al. Brain Metastases in Havana Cancer Patients. MEDICC Rev. 2018;20(1):18doi: 10.37757/MR2018.V20.N1.5.
Caballero-García, J., Jiménez-Martínez, R., Giol-Álvarez, A. M., Caso-Cantero, M. J., Cruz-García, O., & García-López, D. L. �. �. (2018). Brain Metastases in Havana Cancer Patients. MEDICC review, 20(1), 18. https://doi.org/10.37757/MR2018.V20.N1.5
Caballero-García, Joel, et al. "Brain Metastases in Havana Cancer Patients." MEDICC review vol. 20,1 (2018): 18. doi: https://doi.org/10.37757/MR2018.V20.N1.5
Caballero-García J, Jiménez-Martínez R, Giol-Álvarez AM, Caso-Cantero MJ, Cruz-García O, García-López DLÁ. Brain Metastases in Havana Cancer Patients. MEDICC Rev. 2018 Jan;20(1):18. doi: 10.37757/MR2018.V20.N1.5. Epub 2018 Feb 10. PMID: 34229417.
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MEDICC Rev. 2018 Jan;20(1):18. doi: 10.37757/MR2018.V20.N1.5. Epub 2018 Feb 10.

Brain Metastases in Havana Cancer Patients.

MEDICC review

Joel Caballero-García, Rosainerys Jiménez-Martínez, Adolfo M Giol-Álvarez, Mario de Jesús Caso-Cantero, Orlando Cruz-García, Diana de Los Ángeles García-López

Affiliations

  1. National Oncology and Radiobiology Institute (INOR), Havana, Cuba.
  2. Wilfredo Santana Rivas Polyclinic, Habana del Este, Havana, Cuba.
  3. Juan Manuel Márquez Pediatric Teaching Hospital, Havana, Cuba.
  4. Gregorio Valdés Cruz Polyclinic, Habana del Este, Havana, Cuba.
  5. Ramón González Coro University Maternity Hospital, Havana, Cuba.

PMID: 34229417 DOI: 10.37757/MR2018.V20.N1.5

Abstract

INTRODUCTION: Cancer is a major public health problem worldwide and in Cuba. Approximately one third of cancer patients develop a brain metastasis. Despite this, epidemiological studies are scarce, internationally and in Cuba; published research is mainly limited to autopsy studies and hospital case series.

OBJECTIVE: Characterize patients with brain metastases residing in Habana del Este Municipality, Havana, Cuba, with respect to demographics, metastasis location and primary tumor site.

METHODS: A retrospective descriptive study was carried out with data for all patients with histologically confirmed cancer diagnosed in 2014 and registered in primary health care in Habana del Este Municipality. Diagnostic reports from computed tomography and/or magnetic resonance imaging were used to identify patients with brain metastases. Study variables were age, sex, skin color, number and location of brain metastases, control of primary tumor, and presence of extracranial metastases. Percentages were calculated and presented in tables.

RESULTS: We identified 832 cancer patients in the Habana del Este population of 181,473 (prevalence 458.5 per 100,000 population). Among patients with cancer, 27.6% (230/832) had brain tumors, among which 83% (191/230) were brain metastases and 17% (39/230) primary tumors, a ratio of 4.9:1. Brain metastases appeared in 23% (191/832) of cancer patients (prevalence 105.2 per 100,000 population). Among patients with brain metastases, 48.2% (92/191) were aged 41-60 years and 61.3% (117/191) were female sex. The majority, 59.7% (114/191) had multiple metastases. The most frequent primary tumor location was the breast (40.8%, 78/191), followed by the lung (31.9%; 61/191); 46.8% (211/451) of brain metastases were in the parietal lobe.

CONCLUSIONS: Brain metastases are more prevalent in this Cuban municipality than reported in other countries, but they constitute a higher proportion of cancer cases than seen in other population-based studies. The study's results underline the importance of detecting brain metastasis early, to permit timely interventions to improve quality of life and survival.

CONTRIBUTION OF THIS RESEARCH: This is the first epidemiological study of brain metastases in Cuba and one of the few carried out internationally.

Keywords: Cancer; Cuba; epidemiology; neoplasm metastasis; prevalence; tumor metastasis/brain

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