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Bellarosa C, Bedogni G, Bianco A, et al. Association of Serum Bilirubin Level with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study of 1672 Obese Children. J Clin Med. 2021;10(13)doi: 10.3390/jcm10132812.
Bellarosa, C., Bedogni, G., Bianco, A., Cicolini, S., Caroli, D., Tiribelli, C., & Sartorio, A. (2021). Association of Serum Bilirubin Level with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study of 1672 Obese Children. Journal of clinical medicine, 10(13), . https://doi.org/10.3390/jcm10132812
Bellarosa, Cristina, et al. "Association of Serum Bilirubin Level with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study of 1672 Obese Children." Journal of clinical medicine vol. 10,13 (2021). doi: https://doi.org/10.3390/jcm10132812
Bellarosa C, Bedogni G, Bianco A, Cicolini S, Caroli D, Tiribelli C, Sartorio A. Association of Serum Bilirubin Level with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study of 1672 Obese Children. J Clin Med. 2021 Jun 25;10(13). doi: 10.3390/jcm10132812. PMID: 34202304; PMCID: PMC8268762.
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J Clin Med. 2021 Jun 25;10(13). doi: 10.3390/jcm10132812.

Association of Serum Bilirubin Level with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study of 1672 Obese Children.

Journal of clinical medicine

Cristina Bellarosa, Giorgio Bedogni, Annalisa Bianco, Sabrina Cicolini, Diana Caroli, Claudio Tiribelli, Alessandro Sartorio

Affiliations

  1. Italian Liver Foundation, 34149 Trieste, Italy.
  2. Life Science Department, University of Trieste, 34127 Trieste, Italy.
  3. Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-Endocrinological Research, 28824 Verbania, Italy.
  4. Istituto Auxologico Italiano, IRCCS, Division of Auxology and Metabolic Diseases, 28824 Verbania, Italy.

PMID: 34202304 PMCID: PMC8268762 DOI: 10.3390/jcm10132812

Abstract

As in adults, obesity also plays a central role in the development of metabolic syndrome (MS) in children. Non-alcoholic fatty liver disease (NAFLD) is considered a manifestation of MS. Not only MS but also NAFLD seem to be inversely associated with serum bilirubin concentrations, an important endogenous tissue protector when only mild elevated. The aim of the study was to evaluate the association between serum bilirubin levels and the prevalence of MS and NAFLD in Italian obese children and adolescents. A retrospective cross-sectional study was performed in 1672 patients aged from 5 to 18 years. Clinical and laboratory parameters were assessed. NAFLD was measured by liver ultrasonography. The study was approved by the Ethical Committee of the Istituto Auxologico Italiano (research project code 1C021_2020, acronym BILOB). MS was present in 24% and fatty liver (FL) in 38% of this population. Bilirubin was not associated with FL and MS as a whole, but it was inversely associated only with selected components of MS, i.e., large WC, high blood pressure and high triglycerides. Our data suggest that bilirubin is not protective against MS and NAFLD in the presence of severe obesity.

Keywords: adolescents; bilirubin; children; cross-sectional study; fatty liver; metabolic syndrome; non-alcoholic fatty liver disease; obesity

References

  1. J Endocrinol Invest. 2006 Jul-Aug;29(7):581-93 - PubMed
  2. Clin Sci (Lond). 2013 Sep;125(5):257-64 - PubMed
  3. N Engl J Med. 1995 Nov 2;333(18):1171-5 - PubMed
  4. Exp Gerontol. 2015 Dec;72:63-6 - PubMed
  5. BMC Endocr Disord. 2020 Jul 22;20(1):110 - PubMed
  6. J Pediatr. 2003 Oct;143(4):500-5 - PubMed
  7. Gastroenterology. 1984 Aug;87(2):308-13 - PubMed
  8. J Am Heart Assoc. 2017 Nov 13;6(11): - PubMed
  9. Ann Hepatol. 2004 Apr-Jun;3(2):63-5 - PubMed
  10. Clin Biochem. 2011 Mar;44(4):300-3 - PubMed
  11. Liver Int. 2008 May;28(5):592-605 - PubMed
  12. J Pediatr Gastroenterol Nutr. 2013 Jul;57(1):114-8 - PubMed
  13. PLoS One. 2014 Jun 05;9(6):e98467 - PubMed
  14. Diabetes Res Clin Pract. 2010 Apr;88(1):14-21 - PubMed
  15. Przegl Epidemiol. 2012;66(3):495-501 - PubMed
  16. Clin Chim Acta. 2010 Oct 9;411(19-20):1496-501 - PubMed
  17. Circulation. 2003 Jan 28;107(3):363-9 - PubMed
  18. Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):716-24 - PubMed
  19. Clin Endocrinol (Oxf). 2008 Jun;68(6):868-72 - PubMed
  20. Diabetes Care. 2005 Jul;28(7):1769-78 - PubMed
  21. Hepatology. 2005 Sep;42(3):641-9 - PubMed
  22. J Pediatr Gastroenterol Nutr. 2009 Sep;49(3):329-34 - PubMed
  23. Dig Liver Dis. 2007 Apr;39(4):351-5 - PubMed
  24. Eur J Epidemiol. 2020 Feb;35(2):123-137 - PubMed
  25. Nutr Metab Cardiovasc Dis. 2013 Jan;23(1):31-7 - PubMed
  26. Atherosclerosis. 1997 May;131(1):107-13 - PubMed
  27. Hepatology. 2005 Feb;41(2):372-9 - PubMed
  28. J Pharm Pharmacol. 2013 Jun;65(6):874-83 - PubMed
  29. Circulation. 2009 Oct 20;120(16):1640-5 - PubMed
  30. Clin Mol Hepatol. 2012 Dec;18(4):383-90 - PubMed
  31. Atherosclerosis. 2018 Feb;269:306-311 - PubMed
  32. J Pediatr Gastroenterol Nutr. 1997 Mar;24(3):317-21 - PubMed
  33. Obes Rev. 2015 Jan;16(1):1-12 - PubMed
  34. Hepatology. 2004 Dec;40(6):1387-95 - PubMed
  35. Liver Int. 2009 Feb;29(2):315-6 - PubMed
  36. J Diabetes. 2011 Sep;3(3):217-24 - PubMed
  37. N Engl J Med. 2004 Jun 3;350(23):2362-74 - PubMed
  38. Diabetol Int. 2016 Sep 21;7(4):338-341 - PubMed
  39. Korean J Fam Med. 2011 Sep;32(6):327-33 - PubMed
  40. J Atheroscler Thromb. 2011;18(5):403-12 - PubMed
  41. Neuro Endocrinol Lett. 2011;32(3):360-4 - PubMed
  42. Curr Opin Endocrinol Diabetes Obes. 2008 Feb;15(1):21-9 - PubMed
  43. Int J Endocrinol. 2020 Jul 29;2020:5681296 - PubMed
  44. Obes Facts. 2013;6(1):48-56 - PubMed
  45. Diabetes Res Clin Pract. 2010 Apr;88(1):103-10 - PubMed
  46. Lancet. 2014 Aug 30;384(9945):766-81 - PubMed
  47. Diabetol Metab Syndr. 2015 Jan 23;7:4 - PubMed
  48. Front Pharmacol. 2012 Apr 03;3:55 - PubMed
  49. Int J Biochem Cell Biol. 2013 Dec;45(12):2843-51 - PubMed
  50. Clin Pharmacol Ther. 2019 Sep;106(3):568-575 - PubMed
  51. Hepatology. 2003 May;37(5):1202-19 - PubMed
  52. Atherosclerosis. 2008 Aug;199(2):390-6 - PubMed
  53. PLoS One. 2015 Oct 29;10(10):e0140908 - PubMed
  54. Endocrine. 2011 Apr;39(2):182-9 - PubMed
  55. Hepatology. 2003 Apr;37(4):917-23 - PubMed
  56. Hepatology. 2004 Oct;40(4):827-35 - PubMed
  57. Diabetes Metab. 2018 Sep;44(4):346-353 - PubMed
  58. Pharm Res. 1999 Feb;16(2):191-7 - PubMed
  59. Diabetes Care. 2004 Jun;27(6):1487-95 - PubMed
  60. J Gastroenterol Hepatol. 2013 Jul;28(7):1202-8 - PubMed
  61. Arch Dis Child. 1976 Mar;51(3):170-9 - PubMed
  62. Lancet. 2007 Jun 23;369(9579):2059-61 - PubMed
  63. Hepatology. 2005 Jul;42(1):44-52 - PubMed
  64. Diabetes Metab. 2016 Dec;42(6):389-397 - PubMed
  65. Clin Chem Lab Med. 2011 Nov;49(11):1823-8 - PubMed
  66. Pediatrics. 2009 Dec;124(6):e1221-7 - PubMed
  67. Int J Hypertens. 2011 Feb 22;2011:257168 - PubMed
  68. Front Genet. 2018 Dec 18;9:662 - PubMed
  69. Atherosclerosis. 2009 Apr;203(2):563-8 - PubMed
  70. Eur J Clin Nutr. 2007 Jul;61(7):877-83 - PubMed
  71. J Gastroenterol Hepatol. 2007 Jun;22(6):841-5 - PubMed
  72. Diabetes Care. 2004 Oct;27(10):2444-9 - PubMed
  73. Br Med J (Clin Res Ed). 1986 Jan 4;292(6512):13-5 - PubMed

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