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Juang RS, Su X, Lee IC. Feasibility Assessment of Parathyroid Hormone Adsorption by Using Polysaccharide-Based Multilayer Film Systems. Polymers (Basel). 2021;13(13)doi: 10.3390/polym13132070.
Juang, R. S., Su, X., & Lee, I. C. (2021). Feasibility Assessment of Parathyroid Hormone Adsorption by Using Polysaccharide-Based Multilayer Film Systems. Polymers, 13(13), . https://doi.org/10.3390/polym13132070
Juang, Ruey-Shin, et al. "Feasibility Assessment of Parathyroid Hormone Adsorption by Using Polysaccharide-Based Multilayer Film Systems." Polymers vol. 13,13 (2021). doi: https://doi.org/10.3390/polym13132070
Juang RS, Su X, Lee IC. Feasibility Assessment of Parathyroid Hormone Adsorption by Using Polysaccharide-Based Multilayer Film Systems. Polymers (Basel). 2021 Jun 24;13(13). doi: 10.3390/polym13132070. PMID: 34202416; PMCID: PMC8271409.
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Polymers (Basel). 2021 Jun 24;13(13). doi: 10.3390/polym13132070.

Feasibility Assessment of Parathyroid Hormone Adsorption by Using Polysaccharide-Based Multilayer Film Systems.

Polymers

Ruey-Shin Juang, Xing Su, I-Chi Lee

Affiliations

  1. Department of Chemical and Materials Engineering, Chang Gung University, Guishan, Taoyuan 33302, Taiwan.
  2. Department of Nephrology, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.
  3. Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan.

PMID: 34202416 PMCID: PMC8271409 DOI: 10.3390/polym13132070

Abstract

Chronic kidney disease (CKD) is a systemic disorder that combines complex bone and mineral abnormalities. The high level of parathyroid hormone (PTH) in the blood causes irreversible renal dysfunction and cardiovascular disease. Therefore, it is necessary to reduce level of PTH in the blood of patients with uremic state. In this study, chitosan and heparin were chosen to form polysaccharide-based multilayer films based on their antibacterial ability, good biocompatibility and hemocompatibility. In addition, a previous study has revealed that PTH is a heparin/polyanion binding protein because of the similarity of heparin to the cell surface proteoglycans. Subsequently, the surface properties including thickness, surface hydrophobicity and surface charge of a series of multilayer films were analyzed. The PTH adsorption rate of a series of multilayer films was also assessed. The results revealed that the optimizing condition is (CHI/HEP)

Keywords: blood compatibility; chronic kidney disease (CKD); parathyroid hormone (PTH) adsorption; polysaccharide-based multilayer films

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