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Avramucz Á, Møller-Olsen C, Grigonyte AM, et al. Analysing Parallel Strategies to Alter the Host Specificity of Bacteriophage T7. Biology (Basel). 2021;10(6)doi: 10.3390/biology10060556.
Avramucz, �. �., Møller-Olsen, C., Grigonyte, A. M., Paramalingam, Y., Millard, A., Sagona, A. P., & Fehér, T. (2021). Analysing Parallel Strategies to Alter the Host Specificity of Bacteriophage T7. Biology, 10(6), . https://doi.org/10.3390/biology10060556
Avramucz, Ákos, et al. "Analysing Parallel Strategies to Alter the Host Specificity of Bacteriophage T7." Biology vol. 10,6 (2021). doi: https://doi.org/10.3390/biology10060556
Avramucz Á, Møller-Olsen C, Grigonyte AM, Paramalingam Y, Millard A, Sagona AP, Fehér T. Analysing Parallel Strategies to Alter the Host Specificity of Bacteriophage T7. Biology (Basel). 2021 Jun 20;10(6). doi: 10.3390/biology10060556. PMID: 34202963; PMCID: PMC8234382.
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Biology (Basel). 2021 Jun 20;10(6). doi: 10.3390/biology10060556.

Analysing Parallel Strategies to Alter the Host Specificity of Bacteriophage T7.

Biology

Ákos Avramucz, Christian Møller-Olsen, Aurelija M Grigonyte, Yanahan Paramalingam, Andrew Millard, Antonia P Sagona, Tamás Fehér

Affiliations

  1. Synthetic and Systems Biology Unit, Biological Research Centre, Eötvös Loránd Research Network (ELKH), 6726 Szeged, Hungary.
  2. Doctoral School in Biology, University of Szeged, 6726 Szeged, Hungary.
  3. School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK.
  4. Department Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, UK.
  5. Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry CV4 7AL, UK.

PMID: 34202963 PMCID: PMC8234382 DOI: 10.3390/biology10060556

Abstract

The recognition and binding of host bacteria by bacteriophages is most often enabled by a highly specific receptor-ligand type of interaction, with the receptor-binding proteins (RBPs) of phages being the primary determinants of host specificity. Specifically modifying the RBPs could alter or extend the host range of phages otherwise exhibiting desired phenotypic properties. This study employed two different strategies to reprogram T7 phages ordinarily infecting commensal K12

Keywords: BRED; RBP; bacteriophage; host range; host specificity; phage; tail fibres

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