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Carafone LE, Zhang CD, Li D, et al. Diagnostic Accuracy of Dehydroepiandrosterone Sulfate and Corticotropin in Autonomous Cortisol Secretion. Biomedicines. 2021;9(7)doi: 10.3390/biomedicines9070741.
Carafone, L. E., Zhang, C. D., Li, D., Lazik, N., Hamidi, O., Hurtado, M. D., Young, W. F., Thomas, M. A., Dy, B. M., Lyden, M. L., Foster, T. R., McKenzie, T. J., & Bancos, I. (2021). Diagnostic Accuracy of Dehydroepiandrosterone Sulfate and Corticotropin in Autonomous Cortisol Secretion. Biomedicines, 9(7), . https://doi.org/10.3390/biomedicines9070741
Carafone, Lindsay E, et al. "Diagnostic Accuracy of Dehydroepiandrosterone Sulfate and Corticotropin in Autonomous Cortisol Secretion." Biomedicines vol. 9,7 (2021). doi: https://doi.org/10.3390/biomedicines9070741
Carafone LE, Zhang CD, Li D, Lazik N, Hamidi O, Hurtado MD, Young WF, Thomas MA, Dy BM, Lyden ML, Foster TR, McKenzie TJ, Bancos I. Diagnostic Accuracy of Dehydroepiandrosterone Sulfate and Corticotropin in Autonomous Cortisol Secretion. Biomedicines. 2021 Jun 28;9(7). doi: 10.3390/biomedicines9070741. PMID: 34203283; PMCID: PMC8301396.
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Biomedicines. 2021 Jun 28;9(7). doi: 10.3390/biomedicines9070741.

Diagnostic Accuracy of Dehydroepiandrosterone Sulfate and Corticotropin in Autonomous Cortisol Secretion.

Biomedicines

Lindsay E Carafone, Catherine D Zhang, Dingfeng Li, Natalia Lazik, Oksana Hamidi, Maria Daniela Hurtado, William F Young, Melinda A Thomas, Benzon M Dy, Melanie L Lyden, Trenton R Foster, Travis J McKenzie, Irina Bancos

Affiliations

  1. Department of Internal Medicine, May Clinic, Rochester, MN 55902, USA.
  2. Division of Endocrinology, Mayo Clinic, Rochester, MN 55902, USA.
  3. Division of Endocrinology and Metabolism, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  4. Division of Endocrinology, Mayo Clinic Health System, La Crosse, WI 54601, USA.
  5. Department of Surgery, Mayo Clinic, Rochester, MN 55902, USA.

PMID: 34203283 PMCID: PMC8301396 DOI: 10.3390/biomedicines9070741

Abstract

Autonomous cortisol secretion (ACS) affects up to 50% of patients with adrenal adenomas. Despite the limited evidence, clinical guidelines recommend measurement of serum concentrations of dehydroepiandrosterone-sulfate (DHEA-S) and corticotropin (ACTH) to aid in the diagnosis of ACS. Our objective was to determine the accuracy of serum concentrations of DHEA-S and ACTH in diagnosing ACS. We conducted a retrospective single center study of adults with adrenal adenoma evaluated between 2000-2020. Main outcome measure was diagnostic accuracy of DHEA-S and ACTH. ACS was defined as post-dexamethasone cortisol >1.8 mcg/dL. Of 468 patients, ACS was diagnosed in 256 (55%) patients with a median post-DST cortisol of 3.45 mcg/dL (range, 1.9-32.7). Patients with ACS demonstrated lower serum concentrations of DHEA-S (35 vs. 87.3 mcg/dL,

Keywords: adrenal adenoma; adrenal mass; dexamethasone suppression test

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