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Altshuler PJ, Schiazza AR, Luo L, et al. Superoxide Dismutase-Loaded Nanoparticles Attenuate Myocardial Ischemia-Reperfusion Injury and Protect Against Chronic Adverse Ventricular Remodeling. Adv Ther (Weinh). 2021;4(6)doi: 10.1002/adtp.202100036.
Altshuler, P. J., Schiazza, A. R., Luo, L., Helmers, M. R., Chhay, B., Han, J. J., Hu, R., Herbst, D. A., Tsourkas, A., Cheng, Z., & Atluri, P. (2021). Superoxide Dismutase-Loaded Nanoparticles Attenuate Myocardial Ischemia-Reperfusion Injury and Protect Against Chronic Adverse Ventricular Remodeling. Advanced therapeutics, 4(6), . https://doi.org/10.1002/adtp.202100036
Altshuler, Peter J, et al. "Superoxide Dismutase-Loaded Nanoparticles Attenuate Myocardial Ischemia-Reperfusion Injury and Protect Against Chronic Adverse Ventricular Remodeling." Advanced therapeutics vol. 4,6 (2021). doi: https://doi.org/10.1002/adtp.202100036
Altshuler PJ, Schiazza AR, Luo L, Helmers MR, Chhay B, Han JJ, Hu R, Herbst DA, Tsourkas A, Cheng Z, Atluri P. Superoxide Dismutase-Loaded Nanoparticles Attenuate Myocardial Ischemia-Reperfusion Injury and Protect Against Chronic Adverse Ventricular Remodeling. Adv Ther (Weinh). 2021 Jun;4(6). doi: 10.1002/adtp.202100036. Epub 2021 Apr 23. PMID: 34179348; PMCID: PMC8225225.
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Adv Ther (Weinh). 2021 Jun;4(6). doi: 10.1002/adtp.202100036. Epub 2021 Apr 23.

Superoxide Dismutase-Loaded Nanoparticles Attenuate Myocardial Ischemia-Reperfusion Injury and Protect Against Chronic Adverse Ventricular Remodeling.

Advanced therapeutics

Peter J Altshuler, Alexis R Schiazza, Lijun Luo, Mark R Helmers, Bonirath Chhay, Jason J Han, Robin Hu, D Alan Herbst, Andrew Tsourkas, Zhiliang Cheng, Pavan Atluri

Affiliations

  1. Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
  2. Department of Bioengineering, University of Pennsylvania, 210 South 33 Street, 240 Skirkanich Hall, Philadelphia, PA 19104, USA.

PMID: 34179348 PMCID: PMC8225225 DOI: 10.1002/adtp.202100036

Abstract

Early revascularization is critical to reduce morbidity after myocardial infarction, although reperfusion incites additional oxidative injury. Superoxide dismutase (SOD) is an antioxidant that scavenges reactive oxygen species (ROS) but has low endogenous expression and rapid myocardial washout when administered exogenously. This study utilizes a novel nanoparticle carrier to improve exogeneous SOD retention while preserving enzyme function. Its role is assessed in preserving cardiac function after myocardial ischemia-reperfusion (I/R) injury. Here, nanoparticle-encapsulated SOD (NP-SOD) exhibits similar enzyme activity as free SOD, measured by ferricytochrome-c assay. In an

Keywords: ischemia-reperfusion injury; nanoparticle; reactive oxygen species; semipermeable; superoxide dismutase

Conflict of interest statement

Conflicts of Interest The authors declare no conflicts of interest.

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