Display options
Cite
Wercberger R, Braz JM, Weinrich JA, et al. Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons. Proc Natl Acad Sci U S A. 2021;118(28)doi: 10.1073/pnas.2105732118.
Wercberger, R., Braz, J. M., Weinrich, J. A., & Basbaum, A. I. (2021). Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons. Proceedings of the National Academy of Sciences of the United States of America, 118(28), . https://doi.org/10.1073/pnas.2105732118
Wercberger, Racheli, et al. "Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons." Proceedings of the National Academy of Sciences of the United States of America vol. 118,28 (2021). doi: https://doi.org/10.1073/pnas.2105732118
Wercberger R, Braz JM, Weinrich JA, Basbaum AI. Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons. Proc Natl Acad Sci U S A. 2021 Jul 13;118(28). doi: 10.1073/pnas.2105732118. PMID: 34234018; PMCID: PMC8285968.
Copy Download .nbib Format: NLM
Share it on

Proc Natl Acad Sci U S A. 2021 Jul 13;118(28). doi: 10.1073/pnas.2105732118.

Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons.

Proceedings of the National Academy of Sciences of the United States of America

Racheli Wercberger, Joao M Braz, Jarret A Weinrich, Allan I Basbaum

Affiliations

  1. Department of Anatomy, University of California, San Francisco, CA 94158.
  2. Department of Anatomy, University of California, San Francisco, CA 94158 [email protected].

PMID: 34234018 PMCID: PMC8285968 DOI: 10.1073/pnas.2105732118

Abstract

A remarkable molecular and functional heterogeneity of the primary sensory neurons and dorsal horn interneurons transmits pain- and or itch-relevant information, but the molecular signature of the projection neurons that convey the messages to the brain is unclear. Here, using retro-TRAP (translating ribosome affinity purification) and RNA sequencing, we reveal extensive molecular diversity of spino- and trigeminoparabrachial projection neurons. Among the many genes identified, we highlight distinct subsets of

Keywords: RNA-seq; dorsal horn; itch; pain; projection neurons

Conflict of interest statement

The authors declare no competing interest.

References

  1. Annu Rev Physiol. 2018 Feb 10;80:189-217 - PubMed
  2. Sci Rep. 2017 Nov 13;7(1):15466 - PubMed
  3. Cell Rep. 2018 Feb 20;22(8):2216-2225 - PubMed
  4. Neuron. 2019 Feb 6;101(3):412-420.e3 - PubMed
  5. Neuropsychopharmacology. 2018 Aug;43(9):1943-1953 - PubMed
  6. Science. 1983 Jan 21;219(4582):310-2 - PubMed
  7. Cell. 2014 May 22;157(5):1230-42 - PubMed
  8. Scand J Clin Lab Invest Suppl. 2001;234:69-74 - PubMed
  9. J Neurophysiol. 2001 Sep;86(3):1459-80 - PubMed
  10. Neuroscience. 2001;102(1):167-76 - PubMed
  11. J Neurophysiol. 2014 Apr;111(8):1574-89 - PubMed
  12. Science. 1997 Oct 10;278(5336):275-9 - PubMed
  13. Eur J Pharmacol. 1989 Nov 7;170(3):275-9 - PubMed
  14. J Neurophysiol. 1996 Dec;76(6):3656-65 - PubMed
  15. Nat Neurosci. 1998 Jul;1(3):218-25 - PubMed
  16. Mol Pain. 2012 Jul 09;8:52 - PubMed
  17. Nature. 2020 Nov;587(7833):258-263 - PubMed
  18. J Neurosci. 2012 Jun 20;32(25):8686-95 - PubMed
  19. Nat Neurosci. 2018 Jun;21(6):869-880 - PubMed
  20. J Comp Neurol. 2019 Aug 1;527(11):1857-1871 - PubMed
  21. Neuroreport. 2010 Mar 10;21(4):303-8 - PubMed
  22. J Neurophysiol. 2000 Apr;83(4):2239-59 - PubMed
  23. Cell Rep. 2019 May 21;27(8):2508-2523.e4 - PubMed
  24. J Neurosci. 2008 Dec 3;28(49):13150-60 - PubMed
  25. Pain. 2000 Jan;84(1):1-12 - PubMed
  26. J Pharmacol Exp Ther. 2011 Jun;337(3):822-9 - PubMed
  27. J Chem Neuroanat. 2004 Jul;27(4):251-66 - PubMed
  28. J Neuroimmunol. 2014 Sep 15;274(1-2):86-95 - PubMed
  29. J Comp Neurol. 2009 Aug 20;515(6):629-46 - PubMed
  30. J Neurophysiol. 1997 May;77(5):2499-514 - PubMed
  31. Pain. 2015 Oct;156(10):2061-2071 - PubMed
  32. J Neurophysiol. 1970 Mar;33(2):293-307 - PubMed
  33. Neuroscience. 1988 Jan;24(1):195-207 - PubMed
  34. Nature. 2019 Jan;565(7737):86-90 - PubMed
  35. Nat Rev Neurosci. 2014 Jan;15(1):19-31 - PubMed
  36. Eur J Neurosci. 2003 Nov;18(9):2433-48 - PubMed
  37. Neuron. 2017 Feb 22;93(4):840-853.e5 - PubMed
  38. Elife. 2016 Dec 19;5: - PubMed
  39. J Neurosci. 2007 Sep 12;27(37):10007-14 - PubMed
  40. Neuroreport. 1995 Mar 7;6(4):605-8 - PubMed
  41. Nat Rev Neurosci. 2010 Dec;11(12):823-36 - PubMed
  42. Neuroscience. 1996 May;72(1):255-63 - PubMed
  43. J Neurophysiol. 2012 Sep;108(6):1711-23 - PubMed
  44. Science. 2017 Sep 15;357(6356):1149-1155 - PubMed
  45. Somatosens Mot Res. 1993;10(3):309-25 - PubMed
  46. J Neurophysiol. 2004 Jan;91(1):213-22 - PubMed
  47. Prog Clin Biol Res. 1985;176:117-33 - PubMed
  48. Neuron. 2014 May 7;82(3):522-36 - PubMed
  49. Cell Rep. 2020 Nov 24;33(8):108425 - PubMed
  50. Nat Neurosci. 2016 Sep;19(9):1201-9 - PubMed
  51. J Physiol. 1985 Aug;365:197-221 - PubMed
  52. Neuroscience. 2009 Dec 29;164(4):1794-804 - PubMed
  53. Neurosci Lett. 1990 Nov 27;120(1):134-8 - PubMed
  54. J Neurophysiol. 2015 Jan 1;113(1):58-70 - PubMed
  55. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4477-82 - PubMed
  56. Pain. 2020 Jan;161(1):185-194 - PubMed
  57. Cell Rep. 2018 May 15;23(7):2001-2013 - PubMed
  58. J Neurochem. 1999 Feb;72(2):858-67 - PubMed
  59. J Physiol. 1967 Feb;188(3):403-23 - PubMed
  60. J Comp Neurol. 1986 May 22;247(4):505-15 - PubMed
  61. Science. 2016 Nov 4;354(6312):578-584 - PubMed
  62. Brain Res. 1985 Feb 18;327(1-2):169-80 - PubMed
  63. Curr Opin Physiol. 2019 Oct;11:109-115 - PubMed

Publication Types

Grant support