Display options
Share it on

Antibiotics (Basel). 2021 Jun 17;10(6). doi: 10.3390/antibiotics10060734.

Evolution of the Gram-Negative Antibiotic Resistance Spiral over Time: A Time-Series Analysis.

Antibiotics (Basel, Switzerland)

Hajnalka Tóth, Gyula Buchholcz, Adina Fésüs, Bence Balázs, József Bálint Nagy, László Majoros, Krisztina Szarka, Gábor Kardos

Affiliations

  1. Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.
  2. Doctoral School of Pharmaceutical Sciences, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.
  3. Ostalb Klinikum, Im Kälblesrain 1, D-73430 Aalen, Germany.
  4. Central Clinical Pharmacy, Clinical Center, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.
  5. Department of Metagenomics, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.

PMID: 34204497 PMCID: PMC8234935 DOI: 10.3390/antibiotics10060734

Abstract

We followed up the interplay between antibiotic use and resistance over time in a tertiary-care hospital in Hungary. Dynamic relationships between monthly time-series of antibiotic consumption data (defined daily doses per 100 bed-days) and of incidence densities of Gram-negative bacteria (

Keywords: Acinetobacter baumannii; Escherichia coli; Klebsiella spp.; Pseudomonas aeruginosa; antibiotic consumption; antibiotic resistance; carbapenem resistance; cephalosporin resistance; colistin; vector autoregressive models

References

  1. J Med Microbiol. 2017 Mar;66(2):154-159 - PubMed
  2. Curr Opin Infect Dis. 2004 Aug;17(4):309-16 - PubMed
  3. Ann Saudi Med. 2016 May-Jun;36(3):216-22 - PubMed
  4. Lancet Infect Dis. 2013 Dec;13(12):1057-98 - PubMed
  5. Sci Rep. 2015 Oct 19;5:15082 - PubMed
  6. Microbiol Immunol. 2016 May;60(5):285-94 - PubMed
  7. Infect Control Hosp Epidemiol. 2015 Sep;36(9):1065-72 - PubMed
  8. Clin Microbiol Infect. 2005 Oct;11 Suppl 5:4-16 - PubMed
  9. BMC Microbiol. 2016 Sep 06;16(1):205 - PubMed
  10. Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10467-10472 - PubMed
  11. J Antimicrob Chemother. 2017 Jan;72(1):166-171 - PubMed
  12. J Antimicrob Chemother. 2015 Apr;70(4):1212-8 - PubMed
  13. Am J Med Sci. 1996 Jan;311(1):9-16 - PubMed
  14. Int J Antimicrob Agents. 2007 Oct;30(4):360-5 - PubMed
  15. Int J Antimicrob Agents. 2018 Nov;52(5):713-718 - PubMed
  16. Clin Infect Dis. 2019 Sep 27;69(8):1410-1421 - PubMed
  17. Environ Microbiol Rep. 2009 Dec;1(6):469-76 - PubMed
  18. PLoS One. 2010 Apr 07;5(4):e10034 - PubMed
  19. J Glob Antimicrob Resist. 2017 Dec;11:167-170 - PubMed
  20. JAMA. 1998 Oct 14;280(14):1233-7 - PubMed
  21. J Med Microbiol. 2012 Jan;61(Pt 1):71-79 - PubMed
  22. J Med Microbiol. 2014 Dec;63(Pt 12):1654-1662 - PubMed
  23. J Antimicrob Chemother. 2017 Nov 1;72(11):2963-2972 - PubMed
  24. J Antimicrob Chemother. 2011 Jun;66(6):1223-30 - PubMed
  25. Crit Care. 2018 Nov 21;22(1):319 - PubMed
  26. Infect Genet Evol. 2019 Sep;73:411-415 - PubMed
  27. J Hosp Infect. 2014 Apr;86(4):260-6 - PubMed
  28. BMJ Open. 2015 Mar 26;5(3):e006596 - PubMed
  29. Antimicrob Agents Chemother. 2009 Oct;53(10):4264-9 - PubMed
  30. J Antimicrob Chemother. 2017 Dec 1;72(12):3277-3282 - PubMed
  31. Lancet. 2016 Jan 9;387(10014):176-87 - PubMed
  32. BMC Infect Dis. 2014 Jan 09;14:13 - PubMed
  33. PLoS One. 2015 Nov 23;10(11):e0143466 - PubMed
  34. Lancet Infect Dis. 2019 Jan;19(1):56-66 - PubMed
  35. J Antimicrob Chemother. 2011 Jul;66(7):1625-30 - PubMed
  36. Diagn Microbiol Infect Dis. 2014 Jan;78(1):79-84 - PubMed
  37. Antibiotics (Basel). 2021 Jan 29;10(2): - PubMed

Publication Types