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Bimonte S, Cascella M, Forte CA, et al. The Role of Anti-Nerve Growth Factor Monoclonal Antibodies in the Control of Chronic Cancer and Non-Cancer Pain. J Pain Res. 2021;14:1959-1967doi: 10.2147/JPR.S302004.
Bimonte, S., Cascella, M., Forte, C. A., Esposito, G., & Cuomo, A. (2021). The Role of Anti-Nerve Growth Factor Monoclonal Antibodies in the Control of Chronic Cancer and Non-Cancer Pain. Journal of pain research, 141959-1967. https://doi.org/10.2147/JPR.S302004
Bimonte, Sabrina, et al. "The Role of Anti-Nerve Growth Factor Monoclonal Antibodies in the Control of Chronic Cancer and Non-Cancer Pain." Journal of pain research vol. 14 (2021): 1959-1967. doi: https://doi.org/10.2147/JPR.S302004
Bimonte S, Cascella M, Forte CA, Esposito G, Cuomo A. The Role of Anti-Nerve Growth Factor Monoclonal Antibodies in the Control of Chronic Cancer and Non-Cancer Pain. J Pain Res. 2021 Jun 28;14:1959-1967. doi: 10.2147/JPR.S302004. eCollection 2021. PMID: 34234542; PMCID: PMC8253925.
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J Pain Res. 2021 Jun 28;14:1959-1967. doi: 10.2147/JPR.S302004. eCollection 2021.

The Role of Anti-Nerve Growth Factor Monoclonal Antibodies in the Control of Chronic Cancer and Non-Cancer Pain.

Journal of pain research

Sabrina Bimonte, Marco Cascella, Cira Antonietta Forte, Gennaro Esposito, Arturo Cuomo

Affiliations

  1. Division of Anesthesia and Pain Medicine, Istituto Nazionale dei Tumori, IRCCS Fondazione G. Pascale, Naples, Italy.

PMID: 34234542 PMCID: PMC8253925 DOI: 10.2147/JPR.S302004

Abstract

Nerve growth factor (NGF) belongs to the neurotrophin family and plays a fundamental role in the endurance of sensory and sympathetic neurons during embryogenesis. NGF, by interacting with tropomyosin receptor kinase A receptor (TrkA), modulates the pain pathway through the enhancement of the neurotrophic and nociceptor functions. Moreover, it has been demonstrated that NGF is upregulated in patients with chronic pain syndromes, which are difficult to treat. Thus, new non-pharmacological approaches, based on the use of different species-specific monoclonal antibodies (mAbs) targeting the NGF pathway, have been tested for the treatment of chronic pain in preclinical and clinical studies. With regard to preclinical investigations, anti-NGF mAbs have been used for the management of osteoarthritis (OA) and chronic low back pain animal models, with encouraging results. Moreover, anti-NGF mAb therapy is effective in animal models of neuropathic cancer pain. As regards patients with OA, although phase II and phase III clinical trials with tanezumab led to pain reduction, the safety was not observed in all these patients. Here, we review the preclinical and clinical studies on anti-NGF mAb therapy in chronic syndromes, dissect the role of NGF in pain transduction, and highlight the use of anti-NGF mAbs in humans.

© 2021 Bimonte et al.

Keywords: chronic pain; monoclonal antibodies; nerve growth factor; neuropathic cancer pain; peripheral sensitization

Conflict of interest statement

Sabrina Bimonte and Marco Cascella are co-first authors for this study. The authors report no conflicts of interest in this work.

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