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Adornetto A, Gesualdo C, Laganà ML, et al. Autophagy: A Novel Pharmacological Target in Diabetic Retinopathy. Front Pharmacol. 2021;12:695267doi: 10.3389/fphar.2021.695267.
Adornetto, A., Gesualdo, C., Laganà, M. L., Trotta, M. C., Rossi, S., & Russo, R. (2021). Autophagy: A Novel Pharmacological Target in Diabetic Retinopathy. Frontiers in pharmacology, 12695267. https://doi.org/10.3389/fphar.2021.695267
Adornetto, Annagrazia, et al. "Autophagy: A Novel Pharmacological Target in Diabetic Retinopathy." Frontiers in pharmacology vol. 12 (2021): 695267. doi: https://doi.org/10.3389/fphar.2021.695267
Adornetto A, Gesualdo C, Laganà ML, Trotta MC, Rossi S, Russo R. Autophagy: A Novel Pharmacological Target in Diabetic Retinopathy. Front Pharmacol. 2021 Jun 21;12:695267. doi: 10.3389/fphar.2021.695267. eCollection 2021. PMID: 34234681; PMCID: PMC8256993.
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Front Pharmacol. 2021 Jun 21;12:695267. doi: 10.3389/fphar.2021.695267. eCollection 2021.

Autophagy: A Novel Pharmacological Target in Diabetic Retinopathy.

Frontiers in pharmacology

Annagrazia Adornetto, Carlo Gesualdo, Maria Luisa Laganà, Maria Consiglia Trotta, Settimio Rossi, Rossella Russo

Affiliations

  1. Preclinical and Translational Pharmacology, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
  2. Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  3. Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

PMID: 34234681 PMCID: PMC8256993 DOI: 10.3389/fphar.2021.695267

Abstract

Autophagy is the major catabolic pathway involved in removing and recycling damaged macromolecules and organelles and several evidences suggest that dysfunctions of this pathway contribute to the onset and progression of central and peripheral neurodegenerative diseases. Diabetic retinopathy (DR) is a serious complication of diabetes mellitus representing the main preventable cause of acquired blindness worldwide. DR has traditionally been considered as a microvascular disease, however this concept has evolved and neurodegeneration and neuroinflammation have emerged as important determinants in the pathogenesis and evolution of the retinal pathology. Here we review the role of autophagy in experimental models of DR and explore the potential of this pathway as a target for alternative therapeutic approaches.

Copyright © 2021 Adornetto, Gesualdo, Laganà, Trotta, Rossi and Russo.

Keywords: LC3; autophagosomes; autophagy; diabetic retinopathy; hyperglycemia; retinal degeneration

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

  1. Indian J Ophthalmol. 2008 May-Jun;56(3):178-88 - PubMed
  2. Science. 2006 Aug 25;313(5790):1137-40 - PubMed
  3. Diabetes. 2002 Oct;51(10):3107-12 - PubMed
  4. Cell Commun Signal. 2021 Feb 26;19(1):29 - PubMed
  5. Int J Mol Sci. 2020 Jun 14;21(12): - PubMed
  6. Diabetes. 1998 Jun;47(6):859-66 - PubMed
  7. Prog Retin Eye Res. 2016 Mar;51:156-86 - PubMed
  8. Autophagy. 2010 Aug;6(6):764-76 - PubMed
  9. Diabetes. 2015 Mar;64(3):1067 - PubMed
  10. Endocrine. 2017 Jul;57(1):83-88 - PubMed
  11. J Clin Exp Ophthalmol. 2013 Dec 18;4(6): - PubMed
  12. Curr Opin Cell Biol. 2010 Apr;22(2):124-31 - PubMed
  13. Biochem Biophys Res Commun. 2020 Oct 22;531(4):452-458 - PubMed
  14. J Cell Biol. 2010 Apr 19;189(2):211-21 - PubMed
  15. FASEB J. 1999 Jan;13(1):23-30 - PubMed
  16. Ophthalmology. 2003 Sep;110(9):1677-82 - PubMed
  17. Biochem Biophys Res Commun. 2015 Aug 7;463(4):1071-6 - PubMed
  18. Front Pharmacol. 2020 Jul 17;11:1063 - PubMed
  19. Cell Death Differ. 2015 Mar;22(3):476-87 - PubMed
  20. Nature. 2000 Apr 13;404(6779):787-90 - PubMed
  21. J Cell Physiol. 2012 Jun;227(6):2352-62 - PubMed
  22. JCI Insight. 2019 Dec 5;4(23): - PubMed
  23. J Diabetes Res. 2016;2016:2156273 - PubMed
  24. Acta Pharmacol Sin. 2009 Apr;30(4):379-87 - PubMed
  25. Nat Struct Mol Biol. 2013 Jan;20(1):59-66 - PubMed
  26. Diabetologia. 2018 Jan;61(1):29-38 - PubMed
  27. Doc Ophthalmol. 2015 Apr;130(2):131-9 - PubMed
  28. Mol Vis. 2013 Jun 27;19:1413-21 - PubMed
  29. Redox Biol. 2019 Jan;20:1-12 - PubMed
  30. Curr Opin Ophthalmol. 2007 Mar;18(2):110-4 - PubMed
  31. J Clin Invest. 1998 Jan 1;101(1):160-9 - PubMed
  32. Arch Biochem Biophys. 2017 Aug 1;627:10-20 - PubMed
  33. Expert Opin Ther Targets. 2018 Mar;22(3):233-245 - PubMed
  34. Annu Rev Cell Dev Biol. 2011;27:107-32 - PubMed
  35. Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4356-66 - PubMed
  36. Invest Ophthalmol Vis Sci. 2011 May 05;52(6):2967-75 - PubMed
  37. Curr Diab Rep. 2017 Aug 8;17(10):82 - PubMed
  38. Nat Rev Mol Cell Biol. 2018 Jun;19(6):349-364 - PubMed
  39. Cell Physiol Biochem. 2014;33(1):107-16 - PubMed
  40. Biomed Pharmacother. 2020 Dec;132:110818 - PubMed
  41. Antioxid Redox Signal. 2010 Sep 15;13(6):797-805 - PubMed
  42. Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3660-5 - PubMed
  43. Diabetologia. 2012 Nov;55(11):3128-40 - PubMed
  44. Invest Ophthalmol Vis Sci. 2011 Feb 28;52(2):1156-63 - PubMed
  45. Curr Med Chem. 2013;20(26):3218-25 - PubMed
  46. Doc Ophthalmol. 2012 Oct;125(2):123-35 - PubMed
  47. Mol Neurobiol. 2015;51(3):878-84 - PubMed
  48. Invest Ophthalmol Vis Sci. 2011 Jun 13;52(7):4193-9 - PubMed
  49. Ophthalmic Res. 2019;62(4):225-230 - PubMed
  50. Int J Mol Sci. 2018 Jun 20;19(6): - PubMed
  51. J Clin Invest. 2015 Jan;125(1):65-74 - PubMed
  52. Genes Dev. 2007 Nov 15;21(22):2861-73 - PubMed
  53. Glia. 2014 Jul;62(7):1110-24 - PubMed
  54. Diabetologia. 2013 Oct;56(10):2318-28 - PubMed
  55. J Nutr Biochem. 2016 Jul;33:73-81 - PubMed
  56. Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2655-64 - PubMed
  57. Autophagy. 2014 Feb;10(2):192-200 - PubMed
  58. Neurosci Lett. 2011 Aug 26;501(2):102-6 - PubMed
  59. Biomolecules. 2017 Jul 07;7(3): - PubMed
  60. J Clin Med. 2021 Jan 25;10(3): - PubMed
  61. J Diabetes Res. 2020 Mar 1;2020:6086780 - PubMed
  62. Diabetes Care. 2017 Mar;40(3):412-418 - PubMed
  63. Sci Rep. 2015 Nov 24;5:17130 - PubMed
  64. Nat Neurosci. 2009 Jan;12(1):44-52 - PubMed
  65. Int J Mol Sci. 2018 Jan 01;19(1): - PubMed
  66. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2019 Dec 10;36(12):1191-1194 - PubMed
  67. Ophthalmic Res. 2017;57(2):107-117 - PubMed
  68. Cell Death Dis. 2017 May 11;8(5):e2777 - PubMed
  69. Autophagy. 2017 May 4;13(5):941-954 - PubMed
  70. Diabetes Res Clin Pract. 2017 Jun;128:40-50 - PubMed
  71. Clin Exp Ophthalmol. 2016 May;44(4):260-77 - PubMed
  72. Science. 1966 Jan 14;151(3707):209-10 - PubMed
  73. Vision Res. 2017 Oct;139:101-107 - PubMed
  74. Autophagy. 2015;11(1):9-27 - PubMed
  75. Cells. 2020 Apr 07;9(4): - PubMed
  76. Int J Mol Sci. 2019 Aug 01;20(15): - PubMed
  77. Int J Med Sci. 2017 Sep 19;14(12):1203-1212 - PubMed
  78. Curr Opin Pharmacol. 2013 Feb;13(1):72-7 - PubMed
  79. J Pathol. 2010 May;221(1):3-12 - PubMed
  80. Diabetologia. 2001 Jun;44(6):659-73 - PubMed
  81. Mol Neurobiol. 2013 Dec;48(3):702-14 - PubMed
  82. J Clin Invest. 1998 Aug 15;102(4):783-91 - PubMed
  83. Diabetes. 1998 May;47(5):815-20 - PubMed
  84. Exp Cell Res. 2019 Jul 15;380(2):149-158 - PubMed
  85. Pharmacol Res. 2021 Apr;166:105488 - PubMed
  86. Diabetes. 2002 Jul;51(7):2241-8 - PubMed
  87. Antioxid Redox Signal. 2014 Jan 20;20(3):460-73 - PubMed
  88. Life Sci. 2018 Jan 15;193:20-33 - PubMed
  89. Clin Exp Optom. 2012 May;95(3):266-81 - PubMed
  90. Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12222-6 - PubMed
  91. Autophagy. 2021 Jan;17(1):1-382 - PubMed
  92. Nature. 1998 Apr 9;392(6676):605-8 - PubMed
  93. Diabetes Care. 2012 Mar;35(3):556-64 - PubMed
  94. J Cell Biol. 2008 May 5;181(3):497-510 - PubMed
  95. Cells. 2019 Mar 02;8(3): - PubMed
  96. Semin Ophthalmol. 2001 Mar;16(1):31-40 - PubMed
  97. Nature. 2014 Jun 19;510(7505):370-5 - PubMed
  98. Mol Med Rep. 2019 Feb;19(2):927-934 - PubMed
  99. Br J Ophthalmol. 2004 Jan;88(1):145-51 - PubMed
  100. J Clin Invest. 1998 Mar 1;101(5):1142-7 - PubMed
  101. Ophthalmic Res. 2019;62(4):211-217 - PubMed
  102. Diabetes Obes Metab. 2008 Jan;10(1):53-63 - PubMed
  103. J Cell Mol Med. 2010 Oct;14(10):2415-6 - PubMed
  104. J Clin Exp Ophthalmol. 2013 Aug 5;4: - PubMed
  105. Diabetes. 2010 Jun;59(6):1528-38 - PubMed
  106. Eur J Pharmacol. 2021 Mar 15;895:173893 - PubMed
  107. Science. 2004 May 21;304(5674):1158-60 - PubMed
  108. J Biol Chem. 2010 Jul 16;285(29):22576-91 - PubMed
  109. Trends Biochem Sci. 2020 Dec;45(12):1080-1093 - PubMed
  110. Front Med (Lausanne). 2021 Mar 25;8:644121 - PubMed
  111. Exp Ther Med. 2019 Apr;17(4):2945-2952 - PubMed
  112. Nat Cell Biol. 2007 Oct;9(10):1102-9 - PubMed
  113. Diagnostics (Basel). 2020 Jun 17;10(6): - PubMed
  114. Curr Biol. 2018 Feb 19;28(4):R170-R185 - PubMed
  115. Saudi J Ophthalmol. 2018 Oct-Dec;32(4):318-323 - PubMed
  116. J Biol Chem. 1999 Aug 13;274(33):23463-7 - PubMed
  117. Acta Diabetol. 2017 Jun;54(6):527-533 - PubMed
  118. Open Ophthalmol J. 2013;7:4-10 - PubMed
  119. Neuron. 2017 Mar 8;93(5):1015-1034 - PubMed
  120. Sci Rep. 2018 Sep 6;8(1):13321 - PubMed
  121. Biomed Pharmacother. 2018 Jul;103:1408-1414 - PubMed
  122. Cells. 2018 Dec 19;7(12): - PubMed
  123. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Apr;27(2):283-90 - PubMed
  124. Cell Mol Life Sci. 2012 Apr;69(7):1125-36 - PubMed
  125. Autophagy. 2009 Jul;5(5):585-9 - PubMed
  126. Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3369-79 - PubMed
  127. Oncogene. 1997 Oct;15(18):2169-77 - PubMed
  128. Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4867-74 - PubMed
  129. Diabetologia. 2016 Oct;59(10):2251-61 - PubMed
  130. Eye Brain. 2016 Feb 19;8:1-13 - PubMed
  131. Int J Mol Sci. 2017 Aug 28;18(9): - PubMed
  132. Curr Neuropharmacol. 2016;14(8):810-825 - PubMed
  133. Biomed Pharmacother. 2019 Mar;111:1315-1325 - PubMed
  134. Front Cell Neurosci. 2016 Feb 19;10:42 - PubMed
  135. J Neurochem. 2017 Dec;143(5):595-608 - PubMed
  136. Antioxid Redox Signal. 2010 Apr;12(4):537-77 - PubMed
  137. Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1581-87 - PubMed
  138. Am J Ophthalmol. 1994 Oct 15;118(4):445-50 - PubMed
  139. Lancet Glob Health. 2017 Dec;5(12):e1221-e1234 - PubMed
  140. Curr Neuropharmacol. 2014 Jul;12(4):380-6 - PubMed
  141. Mediators Inflamm. 2016;2016:7368389 - PubMed
  142. Int J Endocrinol. 2018 May 2;2018:7492946 - PubMed
  143. Diabetes. 2005 Jun;54(6):1615-25 - PubMed
  144. Med Hypotheses. 2000 May;54(5):814-24 - PubMed
  145. Curr Top Microbiol Immunol. 2009;335:1-32 - PubMed
  146. Pharmacol Res. 2018 Feb;128:167-178 - PubMed
  147. Curr Neuropharmacol. 2016;14(8):831-839 - PubMed
  148. Ophthalmologica. 2012;227(1):1-19 - PubMed
  149. Lancet. 2010 Jul 10;376(9735):124-36 - PubMed
  150. Biochem J. 2008 Feb 15;410(1):1-17 - PubMed
  151. Curr Opin Cell Biol. 2011 Apr;23(2):198-206 - PubMed
  152. Exp Diabetes Res. 2007;2007:43603 - PubMed

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