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Polonskaya YV, Kashtanova EV, Murashov IS, et al. Association of Matrix Metalloproteinases with Coronary Artery Calcification in Patients with CHD. J Pers Med. 2021;11(6)doi: 10.3390/jpm11060506.
Polonskaya, Y. V., Kashtanova, E. V., Murashov, I. S., Striukova, E. V., Kurguzov, A. V., Stakhneva, E. M., Shramko, V. S., Maslatsov, N. A., Chernyavsky, A. M., & Ragino, Y. I. (2021). Association of Matrix Metalloproteinases with Coronary Artery Calcification in Patients with CHD. Journal of personalized medicine, 11(6), . https://doi.org/10.3390/jpm11060506
Polonskaya, Yana V, et al. "Association of Matrix Metalloproteinases with Coronary Artery Calcification in Patients with CHD." Journal of personalized medicine vol. 11,6 (2021). doi: https://doi.org/10.3390/jpm11060506
Polonskaya YV, Kashtanova EV, Murashov IS, Striukova EV, Kurguzov AV, Stakhneva EM, Shramko VS, Maslatsov NA, Chernyavsky AM, Ragino YI. Association of Matrix Metalloproteinases with Coronary Artery Calcification in Patients with CHD. J Pers Med. 2021 Jun 03;11(6). doi: 10.3390/jpm11060506. PMID: 34205079; PMCID: PMC8228219.
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J Pers Med. 2021 Jun 03;11(6). doi: 10.3390/jpm11060506.

Association of Matrix Metalloproteinases with Coronary Artery Calcification in Patients with CHD.

Journal of personalized medicine

Yana V Polonskaya, Elena V Kashtanova, Ivan S Murashov, Evgenia V Striukova, Alexey V Kurguzov, Ekaterina M Stakhneva, Viktoria S Shramko, Nikolay A Maslatsov, Aleksandr M Chernyavsky, Yulia I Ragino

Affiliations

  1. Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of IC&G SB RAS), 175/1 B. Bogatkova Str., 630089 Novosibirsk, Russia.
  2. The Federal State Budgetary Institution "National Medical Research Center Named Academician E.N. Meshalkin" of the Ministry of Health of the Russian Federation, Rechkunovskaya Str., 15, 630055 Novosibirsk, Russia.

PMID: 34205079 PMCID: PMC8228219 DOI: 10.3390/jpm11060506

Abstract

This work is aimed at studying the relationship of matrix metalloproteinases with calcification of the coronary arteries. The study included 78 people with coronary heart disease (CHD) and 36 without CHD. Blood and samples of coronary arteries obtained as a result of endarterectomy were examined. Serum levels of metalloproteinases (MMP) MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-10, MMP-12, and MMP-13 were determined by multiplex analysis. In blood vessel samples, MMP-1, MMP-3, MMP-7, and MMP-9 were determined by enzyme immunoassay; MMP-9 expression was evaluated by immunohistochemistry. Patients with CHD had higher serum levels of MMP-1, MMP-7, and MMP-12. Blood levels of MMP-1 and MMP-3 were associated with calcium levels, MMP-9 with osteoprotegerin and osteonectin, MMP-7 and MMP-10 with osteoprotegerin, MMP-12 with osteocalcin, and MMP-13 with osteopontin. Calcified plaques had higher levels of MMP-1 and MMP-9 compared to plaques without calcification. The relative risk of coronary arteries calcification was associated with MMP-9, which is confirmed by the results of immunohistochemistry. The results obtained indicate the participation of some MMPs, and especially MMP-9, in the calcification processes. The study can serve as a basis for the further study of the possibility of using MMP-1, MMP-7 and MMP-12 as potential biomarkers of CHD.

Keywords: atherosclerosis; calcification; coronary heart disease; metalloproteinases; multiplex assay

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