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Magnan C, Le Stunff H. Role of hypothalamic de novo ceramides synthesis in obesity and associated metabolic disorders. Mol Metab. 2021;53:101298doi: 10.1016/j.molmet.2021.101298.
Magnan, C., & Le Stunff, H. (2021). Role of hypothalamic de novo ceramides synthesis in obesity and associated metabolic disorders. Molecular metabolism, 53101298. https://doi.org/10.1016/j.molmet.2021.101298
Magnan, Christophe, and Le Stunff, Hervé. "Role of hypothalamic de novo ceramides synthesis in obesity and associated metabolic disorders." Molecular metabolism vol. 53 (2021): 101298. doi: https://doi.org/10.1016/j.molmet.2021.101298
Magnan C, Le Stunff H. Role of hypothalamic de novo ceramides synthesis in obesity and associated metabolic disorders. Mol Metab. 2021 Nov;53:101298. doi: 10.1016/j.molmet.2021.101298. Epub 2021 Jul 15. PMID: 34273578; PMCID: PMC8353504.
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Mol Metab. 2021 Nov;53:101298. doi: 10.1016/j.molmet.2021.101298. Epub 2021 Jul 15.

Role of hypothalamic de novo ceramides synthesis in obesity and associated metabolic disorders.

Molecular metabolism

Christophe Magnan, Hervé Le Stunff

Affiliations

  1. Université de Paris, BFA CNRS UMR 8251, Paris, France. Electronic address: [email protected].
  2. CNRS UMR 9198 Institut des Neurosciences Paris Saclay (Neuro-PSI), Université Paris-Saclay, Saclay, France. Electronic address: [email protected].

PMID: 34273578 PMCID: PMC8353504 DOI: 10.1016/j.molmet.2021.101298

Abstract

BACKGROUND: Sphingolipid-mediated signalling pathways are described as important players in the normal functioning of neurons and nonneuronal cells in the central nervous system (CNS).

SCOPE OF REVIEW: This review aims to show role of de novo ceramide synthesis in the CNS in controling key physiological processes, including food intake, energy expenditure, and thermogenesis. The corollary is a condition that leads to a dysfunction in ceramide metabolism in these central regions that can have major consequences on the physiological regulation of energy balance.

MAJOR CONCLUSIONS: Excessive hypothalamic de novo ceramide synthesis has been shown to result in the establishment of central insulin resistance, endoplasmic reticulum stress, and inflammation. Additionally, excessive hypothalamic de novo ceramide synthesis has also been associated with changes in the activity of the autonomic nervous system. Such dysregulation of hypothalamic de novo ceramide synthesis forms the key starting point for the initiation of pathophysiological conditions such as obesity - which may or may not be associated with type 2 diabetes.

Copyright © 2021 The Authors. Published by Elsevier GmbH.. All rights reserved.

Keywords: Ceramides; Food Intake; Hypothalalumus; Obesity; Type 2 diabetes

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