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Radke KL, Wollschläger LM, Nebelung S, et al. Deep Learning-Based Post-Processing of Real-Time MRI to Assess and Quantify Dynamic Wrist Movement in Health and Disease. Diagnostics (Basel). 2021;11(6)doi: 10.3390/diagnostics11061077.
Radke, K. L., Wollschläger, L. M., Nebelung, S., Abrar, D. B., Schleich, C., Boschheidgen, M., Frenken, M., Schock, J., Klee, D., Frahm, J., Antoch, G., Thelen, S., Wittsack, H. J., & Müller-Lutz, A. (2021). Deep Learning-Based Post-Processing of Real-Time MRI to Assess and Quantify Dynamic Wrist Movement in Health and Disease. Diagnostics (Basel, Switzerland), 11(6), . https://doi.org/10.3390/diagnostics11061077
Radke, Karl Ludger, et al. "Deep Learning-Based Post-Processing of Real-Time MRI to Assess and Quantify Dynamic Wrist Movement in Health and Disease." Diagnostics (Basel, Switzerland) vol. 11,6 (2021). doi: https://doi.org/10.3390/diagnostics11061077
Radke KL, Wollschläger LM, Nebelung S, Abrar DB, Schleich C, Boschheidgen M, Frenken M, Schock J, Klee D, Frahm J, Antoch G, Thelen S, Wittsack HJ, Müller-Lutz A. Deep Learning-Based Post-Processing of Real-Time MRI to Assess and Quantify Dynamic Wrist Movement in Health and Disease. Diagnostics (Basel). 2021 Jun 11;11(6). doi: 10.3390/diagnostics11061077. PMID: 34208361; PMCID: PMC8231139.
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Diagnostics (Basel). 2021 Jun 11;11(6). doi: 10.3390/diagnostics11061077.

Deep Learning-Based Post-Processing of Real-Time MRI to Assess and Quantify Dynamic Wrist Movement in Health and Disease.

Diagnostics (Basel, Switzerland)

Karl Ludger Radke, Lena Marie Wollschläger, Sven Nebelung, Daniel Benjamin Abrar, Christoph Schleich, Matthias Boschheidgen, Miriam Frenken, Justus Schock, Dirk Klee, Jens Frahm, Gerald Antoch, Simon Thelen, Hans-Jörg Wittsack, Anja Müller-Lutz

Affiliations

  1. Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, D-40225 Dusseldorf, Germany.
  2. Department of Orthopaedics and Trauma Surgery, Medical Faculty, University Dusseldorf, D-40225 Dusseldorf, Germany.
  3. Department of General Pediatrics, University Children's Hospital, Heinrich-Heine-University Dusseldorf, D-40225 Dusseldorf, Germany.
  4. Biomedizinische NMR, Max-Planck Institute for Biophysical Chemistry, D-37077 Goettingen, Germany.

PMID: 34208361 PMCID: PMC8231139 DOI: 10.3390/diagnostics11061077

Abstract

While morphologic magnetic resonance imaging (MRI) is the imaging modality of choice for the evaluation of ligamentous wrist injuries, it is merely static and incapable of diagnosing dynamic wrist instability. Based on real-time MRI and algorithm-based image post-processing in terms of convolutional neural networks (CNNs), this study aims to develop and validate an automatic technique to quantify wrist movement. A total of 56 bilateral wrists (28 healthy volunteers) were imaged during continuous and alternating maximum ulnar and radial abduction. Following CNN-based automatic segmentations of carpal bone contours, scapholunate and lunotriquetral gap widths were quantified based on dedicated algorithms and as a function of wrist position. Automatic segmentations were in excellent agreement with manual reference segmentations performed by two radiologists as indicated by Dice similarity coefficients of 0.96 ± 0.02 and consistent and unskewed Bland-Altman plots. Clinical applicability of the framework was assessed in a patient with diagnosed scapholunate ligament injury. Considerable increases in scapholunate gap widths across the range-of-motion were found. In conclusion, the combination of real-time wrist MRI and the present framework provides a powerful diagnostic tool for dynamic assessment of wrist function and, if confirmed in clinical trials, dynamic carpal instability that may elude static assessment using clinical-standard imaging modalities.

Keywords: carpal instability; deep learning; dynamic instability; magnetic resonance imaging; real-time; scapholunate ligament injury

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