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Relke N, Chornenki NLJ, Sholzberg M. Tranexamic acid evidence and controversies: An illustrated review. Res Pract Thromb Haemost. 2021;5(5):e12546doi: 10.1002/rth2.12546.
Relke, N., Chornenki, N. L. J., & Sholzberg, M. (2021). Tranexamic acid evidence and controversies: An illustrated review. Research and practice in thrombosis and haemostasis, 5(5), e12546. https://doi.org/10.1002/rth2.12546
Relke, Nicole, et al. "Tranexamic acid evidence and controversies: An illustrated review." Research and practice in thrombosis and haemostasis vol. 5,5 (2021): e12546. doi: https://doi.org/10.1002/rth2.12546
Relke N, Chornenki NLJ, Sholzberg M. Tranexamic acid evidence and controversies: An illustrated review. Res Pract Thromb Haemost. 2021 Jul 14;5(5):e12546. doi: 10.1002/rth2.12546. eCollection 2021 Jul. PMID: 34278187; PMCID: PMC8279901.
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Res Pract Thromb Haemost. 2021 Jul 14;5(5):e12546. doi: 10.1002/rth2.12546. eCollection 2021 Jul.

Tranexamic acid evidence and controversies: An illustrated review.

Research and practice in thrombosis and haemostasis

Nicole Relke, Nicholas L J Chornenki, Michelle Sholzberg

Affiliations

  1. Department of Medicine Queen's University Kingston ON Canada.
  2. Department of Medicine St. Michael's Hospital University of Toronto Toronto ON Canada.
  3. Department of Laboratory Medicine & Pathobiology St. Michael's Hospital University of Toronto Toronto ON Canada.
  4. Division of Hematology Department of Medicine St. Michael's Hospital University of Toronto Toronto ON Canada.

PMID: 34278187 PMCID: PMC8279901 DOI: 10.1002/rth2.12546

Abstract

Tranexamic acid (TXA) is an antifibrinolytic agent commonly used for the treatment or prevention of bleeding. Indications for TXA are diverse, including heavy menstrual bleeding, trauma, postpartum hemorrhage, traumatic brain injury, and surgical site bleeding. Despite decades of use and a robust body of evidence, hesitancy using TXA persists in many clinical settings. This illustrated review describes the history, pharmacology, and practical considerations of TXA use. We also describe the major landmark randomized controlled trials of TXA and their implications. Finally, we review the evidence around common controversies surrounding TXA such as the risk of thrombosis, prescription along with combined hormonal contraceptives, and use in patients with gross hematuria.

© 2021 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis (ISTH).

Keywords: antifibrinolytic agents; blood coagulation; contraceptive agents; thrombosis; tranexamic acid

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