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Rico Montanari N, Ramirez R, Van Buuren N, et al. Transcriptomic analysis of livers of Inactive Carrier HBV patients with differential HBsAg. J Infect Dis. 2021;doi: 10.1093/infdis/jiab381.
Rico Montanari, N., Ramirez, R., Van Buuren, N., van den Bosch, T. P. P., Doukas, M., Debes, J. D., Feierbach, B., & Boonstra, A. (2021). Transcriptomic analysis of livers of Inactive Carrier HBV patients with differential HBsAg. The Journal of infectious diseases, . https://doi.org/10.1093/infdis/jiab381
Rico Montanari, Noe, et al. "Transcriptomic analysis of livers of Inactive Carrier HBV patients with differential HBsAg." The Journal of infectious diseases vol. (2021). doi: https://doi.org/10.1093/infdis/jiab381
Rico Montanari N, Ramirez R, Van Buuren N, van den Bosch TPP, Doukas M, Debes JD, Feierbach B, Boonstra A. Transcriptomic analysis of livers of Inactive Carrier HBV patients with differential HBsAg. J Infect Dis. 2021 Jul 19; doi: 10.1093/infdis/jiab381. Epub 2021 Jul 19. PMID: 34279652.
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J Infect Dis. 2021 Jul 19; doi: 10.1093/infdis/jiab381. Epub 2021 Jul 19.

Transcriptomic analysis of livers of Inactive Carrier HBV patients with differential HBsAg.

The Journal of infectious diseases

Noe Rico Montanari, Ricardo Ramirez, Nick Van Buuren, Thierry P P van den Bosch, Michail Doukas, Jose D Debes, Becket Feierbach, Andre Boonstra

Affiliations

  1. Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands.
  2. Department of Medicine, Division of Gastroenterology & Division of Infectious Diseases, University of Minnesota, Minneapolis, MN, USA.
  3. Gilead Sciences, 333 Lakeside Drive, Foster City, CA, 94494, USA.
  4. Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.

PMID: 34279652 DOI: 10.1093/infdis/jiab381

Abstract

Inactive Carrier phases in chronic hepatitis B virus (HBV) infection present minimal liver disease and HBV replication activity suggesting a partial immune-reconstitution although the mechanisms responsible remain elusive. Moreover, HBsAg production -hypothesized to modulate the immune response- is unaltered. Here, we assessed the intrahepatic transcriptome in Inactive Carrier patients vs healthy liver donors, also in the context of diverse HBsAg levels (serum and liver), to better understand the phenomenon of immune control. We found a de-regulated liver transcriptome in Inactive Carrier patients vs healthy controls despite normal liver function. Moreover, diverse HBsAg levels impacted minimally at the liver transcriptome in Inactive Carrier patients although gene correlation analysis revealed leukocyte activation, recruitment and innate responses genes to correlate with liver HBsAg levels. These findings provide more insight into the mechanisms underlying anti-HBV strategies that are currently under development aimed at interfering with HBsAg production or at inducing a state of immune control.

© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.

Keywords: HBsAg; hepatitis B; intrahepatic transcriptome

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