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Atakpa EC, Brentnall AR, Astley S, et al. The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study. Cancers (Basel). 2021;13(13)doi: 10.3390/cancers13133245.
Atakpa, E. C., Brentnall, A. R., Astley, S., Cuzick, J., Evans, D. G., Warren, R. M. L., Howell, A., & Harvie, M. (2021). The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study. Cancers, 13(13), . https://doi.org/10.3390/cancers13133245
Atakpa, Emma C, et al. "The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study." Cancers vol. 13,13 (2021). doi: https://doi.org/10.3390/cancers13133245
Atakpa EC, Brentnall AR, Astley S, Cuzick J, Evans DG, Warren RML, Howell A, Harvie M. The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study. Cancers (Basel). 2021 Jun 29;13(13). doi: 10.3390/cancers13133245. PMID: 34209579; PMCID: PMC8269424.
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Cancers (Basel). 2021 Jun 29;13(13). doi: 10.3390/cancers13133245.

The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study.

Cancers

Emma C Atakpa, Adam R Brentnall, Susan Astley, Jack Cuzick, D Gareth Evans, Ruth M L Warren, Anthony Howell, Michelle Harvie

Affiliations

  1. Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
  2. Nightingale Breast Screening Centre & Prevent Breast Cancer Unit, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK.
  3. Manchester Breast Centre, The Christie Hospital, Manchester M23 9LT, UK.
  4. Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.
  5. Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust, Manchester M23 9LT, UK.
  6. Manchester Centre for Genomic Medicine, NW Genomic Laboratory Hub, Manchester University Hospitals NHS Foundation Trust, Manchester M13 9WL, UK.
  7. Manchester Academic Health Science Centre, Division of Evolution and Genomic Sciences, Faculty of Biology, School of Biological Sciences, Medicine and Health, University of Manchester, Manchester M23 9LT, UK.
  8. Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
  9. Girton College, University of Cambridge, Cambridge CB3 0JG, UK.
  10. Manchester Academic Health Science Centre, Division of Cancer Sciences, Medicine and Health, University of Manchester, Manchester M23 9LT, UK.

PMID: 34209579 PMCID: PMC8269424 DOI: 10.3390/cancers13133245

Abstract

We evaluated the association between short-term change in body mass index (BMI) and breast density during a 1 year weight-loss intervention (Manchester, UK). We included 65 premenopausal women (35-45 years, ≥7 kg adult weight gain, family history of breast cancer). BMI and breast density (semi-automated area-based, automated volume-based) were measured at baseline, 1 year, and 2 years after study entry (1 year post intervention). Cross-sectional (between-women) and short-term change (within-women) associations between BMI and breast density were measured using repeated-measures correlation coefficients and multivariable linear mixed models. BMI was positively correlated with dense volume between-women (

Keywords: body mass index; breast cancer prevention; breast cancer risk; mammographic density; premenopausal; weight loss

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