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Meltzer EO, Zeiger RS, Dicpinigaitis P, et al. Prevalence and Burden of Chronic Cough in the United States. J Allergy Clin Immunol Pract. 2021;9(11):4037-4044.e2doi: 10.1016/j.jaip.2021.07.022.
Meltzer, E. O., Zeiger, R. S., Dicpinigaitis, P., Bernstein, J. A., Oppenheimer, J. J., Way, N. A., Li, V. W., Boggs, R., Doane, M. J., Urdaneta, E., Weaver, J. P., Schelfhout, J., & Fonseca, E. (2021). Prevalence and Burden of Chronic Cough in the United States. The journal of allergy and clinical immunology. In practice, 9(11), 4037-4044.e2. https://doi.org/10.1016/j.jaip.2021.07.022
Meltzer, Eli O, et al. "Prevalence and Burden of Chronic Cough in the United States." The journal of allergy and clinical immunology. In practice vol. 9,11 (2021): 4037-4044.e2. doi: https://doi.org/10.1016/j.jaip.2021.07.022
Meltzer EO, Zeiger RS, Dicpinigaitis P, Bernstein JA, Oppenheimer JJ, Way NA, Li VW, Boggs R, Doane MJ, Urdaneta E, Weaver JP, Schelfhout J, Fonseca E. Prevalence and Burden of Chronic Cough in the United States. J Allergy Clin Immunol Pract. 2021 Nov;9(11):4037-4044.e2. doi: 10.1016/j.jaip.2021.07.022. Epub 2021 Jul 29. PMID: 34333189.
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J Allergy Clin Immunol Pract. 2021 Nov;9(11):4037-4044.e2. doi: 10.1016/j.jaip.2021.07.022. Epub 2021 Jul 29.

Prevalence and Burden of Chronic Cough in the United States.

The journal of allergy and clinical immunology. In practice

Eli O Meltzer, Robert S Zeiger, Peter Dicpinigaitis, Jonathan A Bernstein, John J Oppenheimer, Nate A Way, Vicky W Li, Robert Boggs, Michael J Doane, Eduardo Urdaneta, Jessica P Weaver, Jonathan Schelfhout, Eileen Fonseca

Affiliations

  1. Department of Pediatrics, University of California, San Diego, Calif. Electronic address: [email protected].
  2. Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, Calif.
  3. Division of Critical Care, Montefiore Medical Center, Bronx, NY.
  4. Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  5. Rutgers New Jersey Medical School, Newark, NJ.
  6. Kantar LLC, New York, NY.
  7. Merck & Co., Inc., Kenilworth, NJ.

PMID: 34333189 DOI: 10.1016/j.jaip.2021.07.022

Abstract

BACKGROUND: Chronic cough is a common complaint but there are little population-based data on its burden in the United States.

OBJECTIVE: To determine the prevalence of chronic cough and its burden on individuals and the health care system.

METHODS: This was a survey of respondents who completed the 2018 National Health and Wellness Survey and questions about sleep and health care resource use. Chronic cough was defined as having a daily cough for 8 or more weeks. Respondents without chronic cough were selected through propensity score matching. Chronic cough prevalence was estimated using poststratification sampling weights calculated using U.S. Census data and post-data Horvitz-Thompson sampling weights to adjust for sampling bias.

RESULTS: Of 74,977 National Health and Wellness Survey respondents, 3,654 had experienced chronic cough in the previous 12 months, for a weighted prevalence of 5.0%. Respondents with chronic cough were older and more predominantly female than respondents without chronic cough (both P < .001). Compared with matched respondents without chronic cough, those with chronic cough had lower mean scores on the Medical Outcomes Study 36-item Short Form Survey v2 physical (P < .001) and mental (P < .001) component summary scores. More respondents with chronic cough than matched controls experienced severe anxiety and severe depression in the past 2 weeks, work productivity impairment, impaired sleep quality and daytime sleepiness, as well as more emergency department visits and hospitalizations in the past 6 months (P < .001 for all comparisons).

CONCLUSIONS: The burden of chronic cough manifests itself as reduced health-related quality of life, increased anxiety and depression, impaired sleep and work productivity, and greater health care utilization.

Copyright © 2021. Published by Elsevier Inc.

Keywords: Chronic cough; Chronic disease; Cough; Prevalence; Quality of life

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