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Bailey LT, Northall SJ, Schalch T. Breakers and amplifiers in chromatin circuitry: acetylation and ubiquitination control the heterochromatin machinery. Curr Opin Struct Biol. 2021;71:156-163doi: 10.1016/j.sbi.2021.06.012.
Bailey, L. T., Northall, S. J., & Schalch, T. (2021). Breakers and amplifiers in chromatin circuitry: acetylation and ubiquitination control the heterochromatin machinery. Current opinion in structural biology, 71156-163. https://doi.org/10.1016/j.sbi.2021.06.012
Bailey, Luke T, et al. "Breakers and amplifiers in chromatin circuitry: acetylation and ubiquitination control the heterochromatin machinery." Current opinion in structural biology vol. 71 (2021): 156-163. doi: https://doi.org/10.1016/j.sbi.2021.06.012
Bailey LT, Northall SJ, Schalch T. Breakers and amplifiers in chromatin circuitry: acetylation and ubiquitination control the heterochromatin machinery. Curr Opin Struct Biol. 2021 Dec;71:156-163. doi: 10.1016/j.sbi.2021.06.012. Epub 2021 Jul 22. PMID: 34303934.
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Curr Opin Struct Biol. 2021 Dec;71:156-163. doi: 10.1016/j.sbi.2021.06.012. Epub 2021 Jul 22.

Breakers and amplifiers in chromatin circuitry: acetylation and ubiquitination control the heterochromatin machinery.

Current opinion in structural biology

Luke T Bailey, Sarah J Northall, Thomas Schalch

Affiliations

  1. Leicester Institute for Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 9HN, UK.
  2. Leicester Institute for Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 9HN, UK. Electronic address: [email protected].

PMID: 34303934 DOI: 10.1016/j.sbi.2021.06.012

Abstract

Eukaryotic genomes are segregated into active euchromatic and repressed heterochromatic compartments. Gene regulatory networks, chromosomal structures, and genome integrity rely on the timely and locus-specific establishment of active and silent states to protect the genome and provide the basis for cell division and specification of cellular identity. Here, we focus on the mechanisms and molecular machinery that establish heterochromatin in Schizosaccharomyces pombe and compare it with Saccharomyces cerevisiae and the mammalian polycomb system. We present recent structural and mechanistic evidence, which suggests that histone acetylation protects active transcription by disrupting the positive feedback loops used by the heterochromatin machinery and that H2A and H3 monoubiquitination actively drives heterochromatin, whereas H2B monoubiquitination mobilizes the defenses to quench heterochromatin.

Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Conflict of interest statement

Conflict of interest statement Nothing declared.

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