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Franconi F, Lemaire L, Gimel JC, et al. NMR diffusometry: A new perspective for nanomedicine exploration. J Control Release. 2021;337:155-167doi: 10.1016/j.jconrel.2021.07.025.
Franconi, F., Lemaire, L., Gimel, J. C., Bonnet, S., & Saulnier, P. (2021). NMR diffusometry: A new perspective for nanomedicine exploration. Journal of controlled release : official journal of the Controlled Release Society, 337155-167. https://doi.org/10.1016/j.jconrel.2021.07.025
Franconi, Florence, et al. "NMR diffusometry: A new perspective for nanomedicine exploration." Journal of controlled release : official journal of the Controlled Release Society vol. 337 (2021): 155-167. doi: https://doi.org/10.1016/j.jconrel.2021.07.025
Franconi F, Lemaire L, Gimel JC, Bonnet S, Saulnier P. NMR diffusometry: A new perspective for nanomedicine exploration. J Control Release. 2021 Sep 10;337:155-167. doi: 10.1016/j.jconrel.2021.07.025. Epub 2021 Jul 16. PMID: 34280413.
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J Control Release. 2021 Sep 10;337:155-167. doi: 10.1016/j.jconrel.2021.07.025. Epub 2021 Jul 16.

NMR diffusometry: A new perspective for nanomedicine exploration.

Journal of controlled release : official journal of the Controlled Release Society

Florence Franconi, Laurent Lemaire, Jean-Christophe Gimel, Samuel Bonnet, Patrick Saulnier

Affiliations

  1. Univ Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France; Univ Angers, PRISM, SFR ICAT, F-49000 Angers, France. Electronic address: [email protected].
  2. Univ Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France; Univ Angers, PRISM, SFR ICAT, F-49000 Angers, France. Electronic address: [email protected].
  3. Univ Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France. Electronic address: [email protected].
  4. Univ Angers, PRISM, SFR ICAT, F-49000 Angers, France. Electronic address: [email protected].
  5. Univ Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France. Electronic address: [email protected].

PMID: 34280413 DOI: 10.1016/j.jconrel.2021.07.025

Abstract

Nuclear Magnetic Resonance (NMR) based diffusion methods open new perspectives for nanomedicine characterization and their bioenvironment interaction understanding. This review summarizes the theoretical background of diffusion phenomena. Self-diffusion and mutual diffusion coefficient notions are featured. Principles, advantages, drawbacks, and key challenges of NMR diffusometry spectroscopic and imaging methods are presented. This review article also gives an overview of representative applicative works to the nanomedicine field that can contribute to elucidate important issues. Examples of in vitro characterizations such as identification of formulated species, process monitoring, drug release follow-up, nanomedicine interactions with biological barriers are presented as well as possible transpositions for studying in vivo nanomedicine fate.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Diffusion; Magnetic resonance imaging; Magnetic resonance spectroscopy; Nanomedicine; Nuclear magnetic resonance

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