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Jaskuła K, Sacharczuk M, Gaciong Z, et al. Cardiovascular Effects Mediated by HMMR and CD44. Mediators Inflamm. 2021;2021:4977209doi: 10.1155/2021/4977209.
Jaskuła, K., Sacharczuk, M., Gaciong, Z., & Skiba, D. S. (2021). Cardiovascular Effects Mediated by HMMR and CD44. Mediators of inflammation, 20214977209. https://doi.org/10.1155/2021/4977209
Jaskuła, Kinga, et al. "Cardiovascular Effects Mediated by HMMR and CD44." Mediators of inflammation vol. 2021 (2021): 4977209. doi: https://doi.org/10.1155/2021/4977209
Jaskuła K, Sacharczuk M, Gaciong Z, Skiba DS. Cardiovascular Effects Mediated by HMMR and CD44. Mediators Inflamm. 2021 Jul 10;2021:4977209. doi: 10.1155/2021/4977209. eCollection 2021. PMID: 34335086; PMCID: PMC8286199.
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Mediators Inflamm. 2021 Jul 10;2021:4977209. doi: 10.1155/2021/4977209. eCollection 2021.

Cardiovascular Effects Mediated by HMMR and CD44.

Mediators of inflammation

Kinga Jaskuła, Mariusz Sacharczuk, Zbigniew Gaciong, Dominik S Skiba

Affiliations

  1. Department of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Post?pu 36A, Jastrzebiec, Poland.
  2. Faculty of Pharmacy with the Laboratory Medicine Division, Department of Pharmacodynamics, Medical University of Warsaw, Centre for Preclinical Research and Technology, Banacha 1B, Warsaw, Poland.
  3. Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Banacha 1A, Warsaw, Poland.

PMID: 34335086 PMCID: PMC8286199 DOI: 10.1155/2021/4977209

Abstract

Cardiovascular disease (CVD) is the leading cause of death worldwide. The most dangerous life-threatening symptoms of CVD are myocardial infarction and stroke. The causes of CVD are not entirely clear, and new therapeutic targets are still being sought. One of the factors involved in CVD development among vascular damage and oxidative stress is chronic inflammation. It is known that hyaluronic acid plays an important role in inflammation and is regulated by numerous stimuli, including proinflammatory cytokines. The main receptors for hyaluronic acid are CD44 and RHAMM. These receptors are membrane proteins that differ in structure, but it seems that they can perform similar or synergistic functions in many diseases. Both RHAMM and CD44 are involved in cell migration and wound healing. However, their close association with CVD is not fully understood. In this review, we describe the role of both receptors in CVD.

Copyright © 2021 Kinga Jaskuła et al.

Conflict of interest statement

The authors declare that there are no conflicts of interest.

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