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Revand R, Singh SK. Ipsilateral somatic nerves mediate histamine-induced vasosensory reflex responses involving perivascular afferents in rat models. Sci Rep. 2021;11(1):14648doi: 10.1038/s41598-021-94110-x.
Revand, R., & Singh, S. K. (2021). Ipsilateral somatic nerves mediate histamine-induced vasosensory reflex responses involving perivascular afferents in rat models. Scientific reports, 11(1), 14648. https://doi.org/10.1038/s41598-021-94110-x
Revand, Ravindran, and Singh, Sanjeev K. "Ipsilateral somatic nerves mediate histamine-induced vasosensory reflex responses involving perivascular afferents in rat models." Scientific reports vol. 11,1 (2021): 14648. doi: https://doi.org/10.1038/s41598-021-94110-x
Revand R, Singh SK. Ipsilateral somatic nerves mediate histamine-induced vasosensory reflex responses involving perivascular afferents in rat models. Sci Rep. 2021 Jul 19;11(1):14648. doi: 10.1038/s41598-021-94110-x. PMID: 34282171; PMCID: PMC8290047.
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Sci Rep. 2021 Jul 19;11(1):14648. doi: 10.1038/s41598-021-94110-x.

Ipsilateral somatic nerves mediate histamine-induced vasosensory reflex responses involving perivascular afferents in rat models.

Scientific reports

Ravindran Revand, Sanjeev K Singh

Affiliations

  1. Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
  2. Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India. [email protected].

PMID: 34282171 PMCID: PMC8290047 DOI: 10.1038/s41598-021-94110-x

Abstract

Reflex cardiorespiratory alterations elicited after instillation of nociceptive agents intra-arterially (i.a) are termed as 'vasosensory reflex responses'. The present study was designed to evaluate such responses produced after i.a. instillation of histamine (1 mM; 10 mM; 100 mM) and to delineate the pathways i.e. the afferents and efferents mediating these responses. Blood pressure, electrocardiogram and respiratory excursions were recorded before and after injecting saline/histamine, in a local segment of femoral artery in urethane anesthetized rats. Paw edema and latencies of responses were also estimated. Separate groups of experiments were conducted to demonstrate the involvement of somatic nerves in mediating histamine-induced responses after ipsilateral femoral and sciatic nerve sectioning (+NX) and lignocaine pre-treatment (+Ligno). In addition, another set of experiments was performed after bilateral vagotomy (+VagX) and the responses after histamine instillation were studied. Histamine produced concentration-dependent hypotensive, bradycardiac, tachypnoeic and hyperventilatory responses of shorter latencies (2-7 s) favouring the neural mechanisms in eliciting the responses. Instillation of saline (time matched control) in a similar fashion produced no response, excluding the possibilities of ischemic/stretch effects. Paw edema was absent in both hind limbs indicating that the histamine did not reach the paws and did not spill out into the systemic circulation. +NX, +VagX, +Ligno attenuated histamine-induced cardiorespiratory responses significantly. These observations conclude that instillation of 10 mM of histamine produces optimal vasosensory reflex responses originating from the local vascular bed; afferents and efferents of which are mostly located in ipsilateral somatic and vagus nerves respectively.

© 2021. The Author(s).

References

  1. Curr Opin Neurobiol. 1997 Aug;7(4):493-9 - PubMed
  2. Br Med Bull. 1987 Apr;43(2):386-400 - PubMed
  3. Perspect Biol Med. 1960;3:409-17 - PubMed
  4. Nat Neurosci. 2002 Nov;5 Suppl:1062-7 - PubMed
  5. Neurosci Lett. 2009 Oct 30;464(3):199-202 - PubMed
  6. Br J Pharmacol. 1975 Jul;54(3):319-24 - PubMed
  7. MethodsX. 2020 Jul 29;7:101017 - PubMed
  8. Toxicon. 1981;19(6):807-23 - PubMed
  9. Neurosci Lett. 2008 Jun 13;438(1):64-6 - PubMed
  10. Toxicon. 2005 Dec 1;46(7):820-6 - PubMed
  11. Naunyn Schmiedebergs Arch Pharmacol. 1982 Jul;320(1):54-7 - PubMed
  12. J Neurosci. 1999 Mar 15;19(6):2181-6 - PubMed
  13. Physiol Rev. 1973 Jan;53(1):159-227 - PubMed
  14. J Neurochem. 1998 Mar;70(3):1217-26 - PubMed
  15. J Physiol. 1977 Mar;265(3):795-807 - PubMed
  16. Naunyn Schmiedebergs Arch Pharmacol. 1983 Dec;324(4):293-5 - PubMed
  17. J Physiol. 1988 Sep;403:91-104 - PubMed
  18. Br J Clin Pharmacol. 2013 Nov;76(5):699-707 - PubMed
  19. Physiol Int. 2020 Mar;107(1):40-54 - PubMed
  20. Nature. 2001 Sep 13;413(6852):203-10 - PubMed
  21. Br J Pharmacol. 1975 Oct;55(2):173-9 - PubMed
  22. Br J Pharmacol. 2001 Oct;134(3):655-63 - PubMed
  23. Neurosci Lett. 2009 Feb 27;451(3):194-8 - PubMed
  24. J Physiol. 1998 Mar 15;507 ( Pt 3):843-55 - PubMed
  25. Neurosci Res. 2004 Nov;50(3):271-81 - PubMed
  26. J Physiol. 1926 Apr 23;61(2):215-31 - PubMed
  27. Physiol Rev. 1987 Jan;67(1):67-186 - PubMed
  28. J Neurochem. 1996 Jul;67(1):72-80 - PubMed
  29. Prostaglandins. 1978 Jul;16(1):31-7 - PubMed

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