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Noreldin AE, Gewaily MS, Saadeldin IM, et al. Osteoblast-activating peptide exhibits a specific distribution pattern in mouse ovary and may regulate ovarian steroids and local calcium levels. Am J Transl Res. 2021;13(6):5796-5814
Noreldin, A. E., Gewaily, M. S., Saadeldin, I. M., Abomughaid, M. M., Khafaga, A. F., & Elewa, Y. H. (2021). Osteoblast-activating peptide exhibits a specific distribution pattern in mouse ovary and may regulate ovarian steroids and local calcium levels. American journal of translational research, 13(6), 5796-5814.
Noreldin, Ahmed E, et al. "Osteoblast-activating peptide exhibits a specific distribution pattern in mouse ovary and may regulate ovarian steroids and local calcium levels." American journal of translational research vol. 13,6 (2021): 5796-5814.
Noreldin AE, Gewaily MS, Saadeldin IM, Abomughaid MM, Khafaga AF, Elewa YH. Osteoblast-activating peptide exhibits a specific distribution pattern in mouse ovary and may regulate ovarian steroids and local calcium levels. Am J Transl Res. 2021 Jun 15;13(6):5796-5814. eCollection 2021. PMID: 34306327; PMCID: PMC8290782.
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Am J Transl Res. 2021 Jun 15;13(6):5796-5814. eCollection 2021.

Osteoblast-activating peptide exhibits a specific distribution pattern in mouse ovary and may regulate ovarian steroids and local calcium levels.

American journal of translational research

Ahmed E Noreldin, Mahmoud S Gewaily, Islam M Saadeldin, Mosleh M Abomughaid, Asmaa F Khafaga, Yaser H Elewa

Affiliations

  1. Department of Histology and Cytology, Faculty of Veterinary Medicine, Scientific Campus, Damanhour University Damanhour 22511, Egypt.
  2. Veterinary Anatomy, Faculty of Agriculture, Tottori University Tottori, Japan.
  3. Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Kafrelsheikh University Kafrelsheikh 33516, Egypt.
  4. Department of Physiology, Faculty of Veterinary Medicine, Zagazig University Zagazig 44519, Egypt.
  5. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha Bisha 61922, Saudi Arabia.
  6. Department of Pathology, Faculty of Veterinary Medicine, Alexandria University Edfina 22758, Egypt.
  7. Laboratory of Anatomy, Faculty of Veterinary Medicine, Basic Veterinary Sciences, Hokkaido University Sapporo 060-0818, Japan.
  8. Department of Histology, Faculty of Veterinary Medicine, Zagazig University Zagazig 44519, Egypt.

PMID: 34306327 PMCID: PMC8290782

Abstract

Osteoblast-activating peptide (OBAP) is a novel protein affecting osteoblast proliferation and differentiation, but its ovarian expression is yet to be reported. Osteoporosis is a common disease, caused mainly by low estrogen levels in females. We investigated whether OBAP regulates estrogen synthesis and osteoporosis. Using immunohistochemical analyses, we studied the distribution of OBAP in different parts of the mouse ovary. We also attempted to clarify the correlation of OBAP with ovarian steroids and calcium-regulating factors in the same ovarian tissues, including aromatase (CYP19), 3β-hydroxysteroid dehydrogenase (3β-HSD), estrogen receptor (ER), progesterone receptor (PR), receptor activator of nuclear factor-κB (RANK), calmodulin, calbindin, and calcium-sensing receptor. The ovarian interstitial endocrine cells (IC) showed the greatest localization of OBAP, followed by the mature corpus luteum and the oocytes of mature Graafian follicles (MGF), while there were strong negative correlations of OBAP with CYP19. Strong positive correlations with 3β-HSD (except MGF), RANK (except IC), and calmodulin (except MGF and IC) were demonstrated. OBAP also showed partially positive correlations with ER and PR in the corpus luteum and with IC and calbindin in the MGF. We conclude that OBAP might be related to estrogen synthesis and calcium homeostasis.

AJTR Copyright © 2021.

Keywords: OBAP; Ovary; calcium homeostasis; estrogen; immunohistochemistry

Conflict of interest statement

None.

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