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Gwozdzinski L, Pieniazek A, Bernasinska-Slomczewska J, et al. Alterations in the Plasma and Red Blood Cell Properties in Patients with Varicose Vein: A Pilot Study. Cardiol Res Pract. 2021;2021:5569961doi: 10.1155/2021/5569961.
Gwozdzinski, L., Pieniazek, A., Bernasinska-Slomczewska, J., Hikisz, P., & Gwozdzinski, K. (2021). Alterations in the Plasma and Red Blood Cell Properties in Patients with Varicose Vein: A Pilot Study. Cardiology research and practice, 20215569961. https://doi.org/10.1155/2021/5569961
Gwozdzinski, Lukasz, et al. "Alterations in the Plasma and Red Blood Cell Properties in Patients with Varicose Vein: A Pilot Study." Cardiology research and practice vol. 2021 (2021): 5569961. doi: https://doi.org/10.1155/2021/5569961
Gwozdzinski L, Pieniazek A, Bernasinska-Slomczewska J, Hikisz P, Gwozdzinski K. Alterations in the Plasma and Red Blood Cell Properties in Patients with Varicose Vein: A Pilot Study. Cardiol Res Pract. 2021 Jun 30;2021:5569961. doi: 10.1155/2021/5569961. eCollection 2021. PMID: 34306747; PMCID: PMC8263278.
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Cardiol Res Pract. 2021 Jun 30;2021:5569961. doi: 10.1155/2021/5569961. eCollection 2021.

Alterations in the Plasma and Red Blood Cell Properties in Patients with Varicose Vein: A Pilot Study.

Cardiology research and practice

Lukasz Gwozdzinski, Anna Pieniazek, Joanna Bernasinska-Slomczewska, Pawel Hikisz, Krzysztof Gwozdzinski

Affiliations

  1. Department of Pharmacology and Toxicology, Medical University of Lodz, Lodz, Poland.
  2. Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.

PMID: 34306747 PMCID: PMC8263278 DOI: 10.1155/2021/5569961

Abstract

The varicose vein results from the inefficient functioning of the valves in the lower limb veins, making the blood flow slow down and leading to blood stasis and hypoxia. This type of vein dysfunction might be a result of the development of oxidative stress. We compared oxidative stress markers in the plasma and erythrocytes obtained from peripheral veins and varicose veins in the same patients (glutathione, nonenzymatic antioxidant capacity (NEAC), catalase (CAT) and acetylcholinesterase (AChE) activity, thiols, thiobarbituric acid-reactive substance (TBARS), and protein carbonyls). We found a decrease in NEAC in the plasma obtained from the varicose veins compared to the peripheral veins. We detected a decrease in thiols in the plasma, hemolysate, and plasma membranes and increase in protein carbonyl compounds and TBARS levels in the varicose veins. These changes were accompanied by a decrease in CAT and AChE activity. For the first time, our results show changes in the plasma, erythrocyte membrane, and hemolysate protein properties in varicose vein blood in contrast to the plasma and erythrocytes in peripheral vein blood from the same patients. The increased oxidative stress accompanying varicose vein disease might result from the local inefficiency of the antioxidant defense system.

Copyright © 2021 Lukasz Gwozdzinski et al.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

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