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Boekhoff S, Bison B, Genzel D, et al. Cerebral Infarction in Childhood-Onset Craniopharyngioma Patients: Results of KRANIOPHARYNGEOM 2007. Front Oncol. 2021;11:698150doi: 10.3389/fonc.2021.698150.
Boekhoff, S., Bison, B., Genzel, D., Eveslage, M., Otte, A., Friedrich, C., Flitsch, J., & Müller, H. L. (2021). Cerebral Infarction in Childhood-Onset Craniopharyngioma Patients: Results of KRANIOPHARYNGEOM 2007. Frontiers in oncology, 11698150. https://doi.org/10.3389/fonc.2021.698150
Boekhoff, Svenja, et al. "Cerebral Infarction in Childhood-Onset Craniopharyngioma Patients: Results of KRANIOPHARYNGEOM 2007." Frontiers in oncology vol. 11 (2021): 698150. doi: https://doi.org/10.3389/fonc.2021.698150
Boekhoff S, Bison B, Genzel D, Eveslage M, Otte A, Friedrich C, Flitsch J, Müller HL. Cerebral Infarction in Childhood-Onset Craniopharyngioma Patients: Results of KRANIOPHARYNGEOM 2007. Front Oncol. 2021 Jul 14;11:698150. doi: 10.3389/fonc.2021.698150. eCollection 2021. PMID: 34336685; PMCID: PMC8317984.
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Front Oncol. 2021 Jul 14;11:698150. doi: 10.3389/fonc.2021.698150. eCollection 2021.

Cerebral Infarction in Childhood-Onset Craniopharyngioma Patients: Results of KRANIOPHARYNGEOM 2007.

Frontiers in oncology

Svenja Boekhoff, Brigitte Bison, Daniela Genzel, Maria Eveslage, Anna Otte, Carsten Friedrich, Jörg Flitsch, Hermann L Müller

Affiliations

  1. Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Carl von Ossietzky University, Klinikum Oldenburg AöR, Oldenburg, Germany.
  2. Department of Neuroradiology, University Hospital Würzburg, Würzburg, Germany.
  3. Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany.
  4. Department of Neurosurgery, University Hospital Hamburg-Eppendorf (UKE), Hamburg, Germany.

PMID: 34336685 PMCID: PMC8317984 DOI: 10.3389/fonc.2021.698150

Abstract

BACKGROUND: Cerebral infarction (CI) is a known vascular complication following treatment of suprasellar tumors. Risk factors for CI, incidence rate, and long-term prognosis are unknown for patients with childhood-onset craniopharyngioma (CP).

METHODS: MRI of 244 CP patients, recruited between 2007 and 2019 in KRANIOPHARYNGEOM 2007, were reviewed for CI. Risk factors for CI and outcome after CI were analyzed.

RESULTS: Twenty-eight of 244 patients (11%) presented with CI based on reference assessment of MRI. One CI occurred before initial surgery and one case of CI occurred after release of intracystic pressure by a cyst catheter. 26 of 28 CI were detected after surgical tumor resection at a median postoperative interval of one day (range: 0.5-53 days). Vascular lesions during surgical procedures were documented in 7 cases with CI. No relevant differences with regard to surgical approaches were found. In all 12 irradiated patients, CI occurred before irradiation. Multivariable analyses showed that hydrocephalus and gross-total resection at the time of primary diagnosis/surgery both were risk factors for CI. After CI, quality of life (PEDQOL) and functional capacity (FMH) were impaired.

CONCLUSIONS: CI occurs in 11% of surgically-treated CP cases. Degree of resection and increased intracranial pressure are risk factors, which should be considered in the planning of surgical procedures for prevention of CI.

Copyright © 2021 Boekhoff, Bison, Genzel, Eveslage, Otte, Friedrich, Flitsch and Müller.

Keywords: cerebral infarction; craniopharyngioma; irradiation; quality of life; surgery

Conflict of interest statement

HM has received reimbursement of participation fees for scientific meetings and continuing medical education events from the following companies: Ferring, Lilly, Pfizer, Sandoz/Hexal, Novo Nordisk, Ip

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