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Betancor M, Moreno-Martínez L, López-Pérez Ó, et al. Therapeutic Assay with the Non-toxic C-Terminal Fragment of Tetanus Toxin (TTC) in Transgenic Murine Models of Prion Disease. Mol Neurobiol. 2021;58(10):5312-5326doi: 10.1007/s12035-021-02489-5.
Betancor, M., Moreno-Martínez, L., López-Pérez, �. �., Otero, A., Hernaiz, A., Barrio, T., Badiola, J. J., Osta, R., Bolea, R., & Martín-Burriel, I. (2021). Therapeutic Assay with the Non-toxic C-Terminal Fragment of Tetanus Toxin (TTC) in Transgenic Murine Models of Prion Disease. Molecular neurobiology, 58(10), 5312-5326. https://doi.org/10.1007/s12035-021-02489-5
Betancor, Marina, et al. "Therapeutic Assay with the Non-toxic C-Terminal Fragment of Tetanus Toxin (TTC) in Transgenic Murine Models of Prion Disease." Molecular neurobiology vol. 58,10 (2021): 5312-5326. doi: https://doi.org/10.1007/s12035-021-02489-5
Betancor M, Moreno-Martínez L, López-Pérez Ó, Otero A, Hernaiz A, Barrio T, Badiola JJ, Osta R, Bolea R, Martín-Burriel I. Therapeutic Assay with the Non-toxic C-Terminal Fragment of Tetanus Toxin (TTC) in Transgenic Murine Models of Prion Disease. Mol Neurobiol. 2021 Oct;58(10):5312-5326. doi: 10.1007/s12035-021-02489-5. Epub 2021 Jul 20. PMID: 34283400; PMCID: PMC8497292.
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Mol Neurobiol. 2021 Oct;58(10):5312-5326. doi: 10.1007/s12035-021-02489-5. Epub 2021 Jul 20.

Therapeutic Assay with the Non-toxic C-Terminal Fragment of Tetanus Toxin (TTC) in Transgenic Murine Models of Prion Disease.

Molecular neurobiology

Marina Betancor, Laura Moreno-Martínez, Óscar López-Pérez, Alicia Otero, Adelaida Hernaiz, Tomás Barrio, Juan José Badiola, Rosario Osta, Rosa Bolea, Inmaculada Martín-Burriel

Affiliations

  1. Centro de Encefalopatías Y Enfermedades Transmisibles Emergentes, Universidad de Zaragoza, IA2, IIS Aragón, 50013, Zaragoza, Spain.
  2. Laboratory of Genetics and Biochemistry (LAGENBIO), Faculty of Veterinary, Institute for Health Research Aragon (IIS Aragón), AgriFood Institute of Aragon (IA2), University of Zaragoza, Miguel Servet 177, 50013, Zaragoza, Spain.
  3. Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos III, Madrid, Spain.
  4. Instituto de Investigación Biomédica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
  5. UMR Institut National de La Recherche Pour L'Agriculture, L'Alimentation Et L'Environment (INRAE)/École Nationale Vétérinaire de Toulouse (ENVT) 1225 IHAP (Interactions Hôtes-Agents Pathogènes), 31076, Toulouse, France.
  6. Centro de Encefalopatías Y Enfermedades Transmisibles Emergentes, Universidad de Zaragoza, IA2, IIS Aragón, 50013, Zaragoza, Spain. [email protected].

PMID: 34283400 PMCID: PMC8497292 DOI: 10.1007/s12035-021-02489-5

Abstract

The non-toxic C-terminal fragment of the tetanus toxin (TTC) has been described as a neuroprotective molecule since it binds to Trk receptors and activates Trk-dependent signaling, activating neuronal survival pathways and inhibiting apoptosis. Previous in vivo studies have demonstrated the ability of this molecule to increase mice survival, inhibit apoptosis and regulate autophagy in murine models of neurodegenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy. Prion diseases are fatal neurodegenerative disorders in which the main pathogenic event is the conversion of the cellular prion protein (PrP

© 2021. The Author(s).

Keywords: Autophagy; Neurodegeneration; Prion; Prion diseases; Tetanus toxin

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