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Ejma M, Madetko N, Brzecka A, et al. The Role of Stem Cells in the Therapy of Stroke. Curr Neuropharmacol. 2021;doi: 10.2174/1570159X19666210806163352.
Ejma, M., Madetko, N., Brzecka, A., Alster, P., Budrewicz, S., Koszewicz, M., Misiuk-Hojło, M., Tomilova, I. K., Somasundaram, S. G., Kirkland, C. E., & Aliev, G. (2021). The Role of Stem Cells in the Therapy of Stroke. Current neuropharmacology, . https://doi.org/10.2174/1570159X19666210806163352
Ejma, Maria, et al. "The Role of Stem Cells in the Therapy of Stroke." Current neuropharmacology vol. (2021). doi: https://doi.org/10.2174/1570159X19666210806163352
Ejma M, Madetko N, Brzecka A, Alster P, Budrewicz S, Koszewicz M, Misiuk-Hojło M, Tomilova IK, Somasundaram SG, Kirkland CE, Aliev G. The Role of Stem Cells in the Therapy of Stroke. Curr Neuropharmacol. 2021 Aug 06; doi: 10.2174/1570159X19666210806163352. Epub 2021 Aug 06. PMID: 34365923.
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Curr Neuropharmacol. 2021 Aug 06; doi: 10.2174/1570159X19666210806163352. Epub 2021 Aug 06.

The Role of Stem Cells in the Therapy of Stroke.

Current neuropharmacology

Maria Ejma, Natalia Madetko, Anna Brzecka, Piotr Alster, Sławomir Budrewicz, Magdalena Koszewicz, Marta Misiuk-Hojło, Irina K Tomilova, Siva G Somasundaram, Cecil E Kirkland, Gjumrakch Aliev

Affiliations

  1. Department of Neurology, Wroclaw Medical University, 50-556 Wroc?aw, Borowska 213. Poland.
  2. Department of Neurology, Medical University of Warsaw, Kondratowicza 8, 03-242 Warszawa. Poland.
  3. Department of Pulmonology and Lung Oncology, Wroclaw Medical University, Grabiszynska 105, 53-439 Wroclaw. Poland.
  4. Department of Ophthalmology, Wroclaw Medical University, 50-556 Wroclaw, Borowska 213. Poland.
  5. Department of Biochemistry, Ivanovo State Medical Academy, Avenue Sheremetyevsky 8, Ivanovo, 153012. Russian Federation.
  6. Department of Biological Sciences, Salem University, Salem, WV, 26426. United States.
  7. Wroclaw Medical University, Department of Pulmonology and Lung Oncology, Wroclaw. Poland.

PMID: 34365923 DOI: 10.2174/1570159X19666210806163352

Abstract

BACKGROUND: Stroke is a major challenge in neurology due to its multifactorial genesis and irreversible consequences. Processes of endogenous post-stroke neurogenesis, although insufficient, may indicate possible direction of future therapy. Multiple research considers stem-cell-based approaches in order to maximize neuroregeneration and minimize post-stroke deficits.

OBJECTIVE: Aim of this study is to review current literature considering post-stroke stem-cell- based therapy and possibilities of inducing neuroregeneration after brain vascular damage.

METHODS: Papers included in this article were obtained from PubMed and MEDLINE databases. The following medical subject headings (MeSH) were used: "stem cell therapy", "post-stroke neurogenesis", "stem-cells stroke", "stroke neurogenesis", "stroke stem cells", "stroke", "cell therapy", "neuroregeneration", "neurogenesis", "stem-cell human", "cell therapy in human". Ultimate inclusion was made after manual review of the obtained reference list.

RESULTS: Attempts of stimulating neuroregeneration after stroke found in current literature include supporting endogenous neurogenesis, different routes of exogenous stem cells supplying and extracellular vesicles used as a method of particle transport.

CONCLUSION: Although further research in this field is required, post stroke brain recovery supported by exogenous stem cells seems to be promising future therapy revolutionizing modern neurology.

Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Keywords: cell therapy; neurogenesis; stroke; stem-cells; extracellular vesicles; central nervous system

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