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Almeida DL, Fabricio GS, Tófolo LP, et al. Early postnatal overnutrition impairs VO. J Dev Orig Health Dis. 2021;1-5doi: 10.1017/S2040174421000428.
Almeida, D. L., Fabricio, G. S., Tófolo, L. P., Ribeiro, T. A., Matiusso, C. C. I., Ribeiro, M. V. G., Oliveira Ferreira, A. R., Pavanello, A., Malta, A., Palma-Rigo, K., & de Freitas Mathias, P. C. (2021). Early postnatal overnutrition impairs VO. Journal of developmental origins of health and disease, 1-5. https://doi.org/10.1017/S2040174421000428
Almeida, Douglas Lopes, et al. "Early postnatal overnutrition impairs VO." Journal of developmental origins of health and disease vol. (2021): 1-5. doi: https://doi.org/10.1017/S2040174421000428
Almeida DL, Fabricio GS, Tófolo LP, Ribeiro TA, Matiusso CCI, Ribeiro MVG, Oliveira Ferreira AR, Pavanello A, Malta A, Palma-Rigo K, de Freitas Mathias PC. Early postnatal overnutrition impairs VO. J Dev Orig Health Dis. 2021 Jul 21;1-5. doi: 10.1017/S2040174421000428. Epub 2021 Jul 21. PMID: 34284843.
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J Dev Orig Health Dis. 2021 Jul 21;1-5. doi: 10.1017/S2040174421000428. Epub 2021 Jul 21.

Early postnatal overnutrition impairs VO.

Journal of developmental origins of health and disease

Douglas Lopes Almeida, Gabriel Sergio Fabricio, Laize Peron Tófolo, Tatiane Aparecida Ribeiro, Camila Cristina Ianoni Matiusso, Maiara Vanusa Guedes Ribeiro, Anna Rebeka Oliveira Ferreira, Audrei Pavanello, Ananda Malta, Kesia Palma-Rigo, Paulo Cezar de Freitas Mathias

Affiliations

  1. Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringá, Paraná, Brazil.
  2. Department of Physiology, State University of Londrina, Londrina, Paraná, Brazil.
  3. Faculdade Adventista Paranaense, Healthy School, Ivatuba, Paraná, Brazil.

PMID: 34284843 DOI: 10.1017/S2040174421000428

Abstract

Exercise counteracts obesity effects, but information on how early-life obesity may affect long-term adaptation to exercise is lacking. This study investigates the impact of early-life postnatal overfeeding (PO) on animals' adaptation to exercise. Only male Wistar rats were used. On postnatal day (PN) 30, rats from control (NL-9 pups) or PO (SL-3 pups) litters were separated into four groups: NL-sedentary (NL-Se), NL-exercised (NL-Ex), SL-sedentary (SL-Se), and SL-exercised (SL-Ex). Exercised groups performed moderate-intensity exercise, running on a treadmill, from PN30 to PN90. Further experiments were carried out between PN90 and PN92. PO promoted obesity in SL versus NL rats (P < 0.05). Exercise reduced body weight (P < 0.001), body fat (P < 0.01), and improved glucose homeostasis in SL-Ex versus SL-Se. SL-Ex presented lower VO2max (P < 0.01) and higher post-exercise LDH (P < 0.05) compared to NL-Ex rats. Although moderate exercise counteracted obesity in SL rats, early-life overnutrition restricts fitness gains in adulthood, indicating that early obesity may impair animals' adaptation to exercise.

Keywords: Early postnatal overfeeding; developmental obesity; moderate exercise; physical fitness

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