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Lim K, Yang JH, Miranda WR, et al. Clinical significance of pulmonary hypertension in patients with constrictive pericarditis. Heart. 2021;107(20):1651-1656doi: 10.1136/heartjnl-2021-319149.
Lim, K., Yang, J. H., Miranda, W. R., Chang, S. A., Jeong, D. S., Nishimura, R. A., Schaff, H., Soo, W. M., Greason, K. L., & Oh, J. K. (2021). Clinical significance of pulmonary hypertension in patients with constrictive pericarditis. Heart (British Cardiac Society), 107(20), 1651-1656. https://doi.org/10.1136/heartjnl-2021-319149
Lim, Kyunghee, et al. "Clinical significance of pulmonary hypertension in patients with constrictive pericarditis." Heart (British Cardiac Society) vol. 107,20 (2021): 1651-1656. doi: https://doi.org/10.1136/heartjnl-2021-319149
Lim K, Yang JH, Miranda WR, Chang SA, Jeong DS, Nishimura RA, Schaff H, Soo WM, Greason KL, Oh JK. Clinical significance of pulmonary hypertension in patients with constrictive pericarditis. Heart. 2021 Oct;107(20):1651-1656. doi: 10.1136/heartjnl-2021-319149. Epub 2021 Jul 20. PMID: 34285103.
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Heart. 2021 Oct;107(20):1651-1656. doi: 10.1136/heartjnl-2021-319149. Epub 2021 Jul 20.

Clinical significance of pulmonary hypertension in patients with constrictive pericarditis.

Heart (British Cardiac Society)

Kyunghee Lim, Jeong Hoon Yang, William R Miranda, Sung-A Chang, Dong Seop Jeong, Rick A Nishimura, Hartzell Schaff, Wern Miin Soo, Kevin L Greason, Jae K Oh

Affiliations

  1. Division of Cardiology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea (the Republic of).
  2. Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of).
  3. Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (the republoic of).
  4. Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA [email protected].
  5. Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Seoul, Korea (the Republic of).
  6. Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
  7. Department of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota, USA.
  8. Department of Cardiology, National University Hospital, Singapore.

PMID: 34285103 DOI: 10.1136/heartjnl-2021-319149

Abstract

OBJECTIVES: We investigated haemodynamics and clinical outcomes according to type of pulmonary hypertension (PH) in patients with constrictive pericarditis (CP).

BACKGROUND: As the prevalence of CP with concomitant myocardial disease (mixed CP) grows, PH is more commonly seen in patients with CP. However, haemodynamic and outcome data according to the presence or absence of PH are limited.

METHODS: 150 patients with surgically confirmed CP who underwent echocardiography and cardiac catheterisation within 7 days at two tertiary centres were divided into three groups: no-PH, isolated postcapillary PH (Ipc-PH) and combined postcapillary and precapillary PH (Cpc-PH). Primary outcome was all-cause mortality during follow-up.

RESULT: In this retrospective cohort study, 110 (73.3%) had PH (mean pulmonary artery pressure ≥25 mm Hg). Cpc-PH, using defined cut-offs for pulmonary vascular resistance (>3 Wood units) or diastolic pulmonary gradient (≥7 mm Hg), was seen in 18 patients (12%). The Cpc-PH group had a higher prevalence of comorbidities (diabetes and atrial fibrillation) and concomitant myocardial disease as an aetiology of CP than other groups. Pulmonary vascular resistance had a significant direct correlation with medial E/e' by Doppler echocardiography (

CONCLUSION: Combined postcapillary and precapillary PH develops in a subset of patients with CP and is associated with long-term mortality after pericardiectomy.

© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.

Keywords: constrictive pericarditis; pulmonary hypertension

Conflict of interest statement

Competing interests: None declared.

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