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Parks C, Rogers CM, Prins P, et al. Genetic Modulation of Initial Sensitivity to Δ9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice. Front Genet. 2021;12:659012doi: 10.3389/fgene.2021.659012.
Parks, C., Rogers, C. M., Prins, P., Williams, R. W., Chen, H., Jones, B. C., Moore, B. M., & Mulligan, M. K. (2021). Genetic Modulation of Initial Sensitivity to Δ9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice. Frontiers in genetics, 12659012. https://doi.org/10.3389/fgene.2021.659012
Parks, Cory, et al. "Genetic Modulation of Initial Sensitivity to Δ9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice." Frontiers in genetics vol. 12 (2021): 659012. doi: https://doi.org/10.3389/fgene.2021.659012
Parks C, Rogers CM, Prins P, Williams RW, Chen H, Jones BC, Moore BM, Mulligan MK. Genetic Modulation of Initial Sensitivity to Δ9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice. Front Genet. 2021 Jul 23;12:659012. doi: 10.3389/fgene.2021.659012. eCollection 2021. PMID: 34367237; PMCID: PMC8343140.
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Front Genet. 2021 Jul 23;12:659012. doi: 10.3389/fgene.2021.659012. eCollection 2021.

Genetic Modulation of Initial Sensitivity to Δ9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice.

Frontiers in genetics

Cory Parks, Chris M Rogers, Pjotr Prins, Robert W Williams, Hao Chen, Byron C Jones, Bob M Moore, Megan K Mulligan

Affiliations

  1. Department of Genetics, Genomics and Informatics, The University of Tennessee Health Science Center, Memphis, TN, United States.
  2. Department of Agriculture, Biology and Health Sciences, Cameron University, Lawton, OK, United States.
  3. Department of Pharmacology, Addiction Science and Toxicology, The University of Tennessee Health Science Center, Memphis, TN, United States.
  4. Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN, United States.

PMID: 34367237 PMCID: PMC8343140 DOI: 10.3389/fgene.2021.659012

Abstract

Cannabinoid receptor 1 activation by the major psychoactive component in cannabis, Δ9-tetrahydrocannabinol (THC), produces motor impairments, hypothermia, and analgesia upon acute exposure. In previous work, we demonstrated significant sex and strain differences in acute responses to THC following administration of a single dose (10 mg/kg,

Copyright © 2021 Parks, Rogers, Prins, Williams, Chen, Jones, Moore and Mulligan.

Keywords: BXD family; C57BL/6; DBA/2; QTL; THC; addiction; cannabis; drug response

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer MD declared a

References

  1. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5780-5 - PubMed
  2. FEBS Lett. 1994 Aug 22;350(2-3):240-4 - PubMed
  3. J Neurosci. 2006 Mar 22;26(12):3210-9 - PubMed
  4. Front Biol (Beijing). 2016 Oct;11(5):376-386 - PubMed
  5. Neuropsychopharmacology. 2013 Jun;38(7):1334-43 - PubMed
  6. Front Mol Neurosci. 2019 May 24;12:128 - PubMed
  7. Genes Brain Behav. 2014 Feb;13(2):213-25 - PubMed
  8. J Comp Neurol. 1999 May 3;407(2):287-301 - PubMed
  9. Methods Mol Biol. 2006;323:79-99 - PubMed
  10. Eur J Nucl Med Mol Imaging. 2013 Oct;40(10):1582-94 - PubMed
  11. Methods Mol Biol. 2017;1488:75-120 - PubMed
  12. Clin Pharmacol Ther. 2009 Mar;85(3):273-6 - PubMed
  13. Nat Neurosci. 2019 Jul;22(7):1066-1074 - PubMed
  14. Addict Biol. 2016 Nov;21(6):1113-1126 - PubMed
  15. Neuroreport. 2017 Jul 5;28(10):565-570 - PubMed
  16. Front Behav Neurosci. 2018 Oct 29;12:250 - PubMed
  17. Psychopharmacology (Berl). 2007 Jun;192(3):325-36 - PubMed
  18. Front Psychiatry. 2014 Jul 31;5:92 - PubMed
  19. Alcohol Clin Exp Res. 1995 Apr;19(2):367-73 - PubMed
  20. Alcohol Clin Exp Res. 2003 Jan;27(1):1-11 - PubMed
  21. Cell. 2012 Sep 14;150(6):1287-99 - PubMed
  22. Nat Neurosci. 2018 Sep;21(9):1161-1170 - PubMed
  23. Mol Neurobiol. 2014 Aug;50(1):149-58 - PubMed
  24. Neuropharmacology. 2011 Dec;61(7):1160-5 - PubMed
  25. Cold Spring Harb Perspect Med. 2013 Feb 01;3(2):a012005 - PubMed
  26. Alcohol Clin Exp Res. 1994 Dec;18(6):1416-22 - PubMed
  27. J Neurosci. 2008 Feb 6;28(6):1385-97 - PubMed
  28. Front Genet. 2012 May 31;3:91 - PubMed
  29. Neurobiol Aging. 2016 Oct;46:58-67 - PubMed
  30. Genes Brain Behav. 2018 Jun;17(5):e12431 - PubMed
  31. Neuropharmacology. 2010 Mar-Apr;58(4-5):799-805 - PubMed
  32. Pharmacol Ther. 2011 Dec;132(3):215-41 - PubMed
  33. Psychopharmacology (Berl). 2016 Feb;233(4):701-14 - PubMed
  34. Arch Gen Psychiatry. 2001 Apr;58(4):322-8 - PubMed
  35. Open Neuropsychopharmacol J. 2009;2:77-85 - PubMed
  36. Int J Neuropsychopharmacol. 2011 Jun;14(5):631-43 - PubMed
  37. Science. 1999 Jan 15;283(5400):401-4 - PubMed
  38. Nat Genet. 2012 Jun 17;44(7):821-4 - PubMed
  39. Eur J Drug Metab Pharmacokinet. 2018 Feb;43(1):1-12 - PubMed
  40. J Allergy Clin Immunol. 2015 Dec;136(6):1664-1672.e14 - PubMed
  41. Neuropsychopharmacology. 2011 Oct;36(11):2339-48 - PubMed
  42. J Neurosci. 2004 Aug 4;24(31):6939-45 - PubMed
  43. Front Genet. 2018 Sep 25;9:370 - PubMed
  44. Nature. 2016 Nov 24;539(7630):555-559 - PubMed
  45. J Pharmacol Exp Ther. 1996 May;277(2):586-94 - PubMed
  46. Transl Psychiatry. 2016 Mar 29;6:e769 - PubMed
  47. Curr Protoc Neurosci. 2017 Apr 10;79:8.39.1-8.39.20 - PubMed
  48. Nat Neurosci. 2009 Sep;12(9):1152-8 - PubMed
  49. Cannabis Cannabinoid Res. 2020 Sep 02;5(3):231-245 - PubMed
  50. Nature. 2005 Oct 13;437(7061):1027-31 - PubMed
  51. Lipids. 2019 Oct;54(10):583-601 - PubMed
  52. Biol Psychiatry. 2012 Oct 15;72(8):637-44 - PubMed
  53. JAMA Psychiatry. 2016 May 1;73(5):472-80 - PubMed
  54. Nat Rev Neurosci. 2015 Oct;16(10):579-94 - PubMed
  55. J Chem Neuroanat. 2000 Dec;20(3-4):349-74 - PubMed
  56. J Neurosci. 2007 Apr 4;27(14):3695-702 - PubMed
  57. Biol Psychiatry. 2011 Jun 1;69(11):1109-16 - PubMed
  58. J Neurochem. 2009 Oct;111(1):37-48 - PubMed
  59. J Neurosci. 2004 Apr 21;24(16):4052-60 - PubMed
  60. Genes Brain Behav. 2010 Mar 1;9(2):129-59 - PubMed
  61. Nat Med. 2006 Mar;12(3):324-9 - PubMed
  62. Biol Psychiatry. 2014 Oct 15;76(8):648-55 - PubMed
  63. J Addict Dis. 1991;10(1-2):73-87 - PubMed
  64. PLoS Biol. 2007 Oct;5(10):e269 - PubMed
  65. Cell Syst. 2021 Mar 17;12(3):235-247.e9 - PubMed
  66. Prog Brain Res. 2008;172:407-20 - PubMed
  67. Neuroscience. 2013 Sep 17;248:670-80 - PubMed
  68. Brain Res. 2016 Aug 15;1645:71-4 - PubMed
  69. Neuropsychopharmacology. 2007 Mar;32(3):607-15 - PubMed

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