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Pan Z, Yang Y, Zhang L, et al. Systemic Contact Dermatitis: The Routes of Allergen Entry. Clin Rev Allergy Immunol. 2021;doi: 10.1007/s12016-021-08873-2.
Pan, Z., Yang, Y., Zhang, L., Zhou, X., Zeng, Y., Tang, R., Chang, C., Sun, J., & Zhang, J. (2021). Systemic Contact Dermatitis: The Routes of Allergen Entry. Clinical reviews in allergy & immunology, . https://doi.org/10.1007/s12016-021-08873-2
Pan, Zhouxian, et al. "Systemic Contact Dermatitis: The Routes of Allergen Entry." Clinical reviews in allergy & immunology vol. (2021). doi: https://doi.org/10.1007/s12016-021-08873-2
Pan Z, Yang Y, Zhang L, Zhou X, Zeng Y, Tang R, Chang C, Sun J, Zhang J. Systemic Contact Dermatitis: The Routes of Allergen Entry. Clin Rev Allergy Immunol. 2021 Aug 02; doi: 10.1007/s12016-021-08873-2. Epub 2021 Aug 02. PMID: 34338976.
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Clin Rev Allergy Immunol. 2021 Aug 02; doi: 10.1007/s12016-021-08873-2. Epub 2021 Aug 02.

Systemic Contact Dermatitis: The Routes of Allergen Entry.

Clinical reviews in allergy & immunology

Zhouxian Pan, Yongshi Yang, Lishan Zhang, Xianjie Zhou, Yueping Zeng, Rui Tang, Christopher Chang, Jinlyu Sun, Jing Zhang

Affiliations

  1. Allergy Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
  2. Dermatology Department, Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, PekingBeijing, 100730, China.
  3. Allergy Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China. [email protected].
  4. Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, Davis, CA, 95616, USA. [email protected].
  5. Division of Pediatric Immunology and Allergy, Joe DiMaggio Children's Hospital, Hollywood, FL, USA. [email protected].
  6. Allergy Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China. [email protected].
  7. Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.

PMID: 34338976 DOI: 10.1007/s12016-021-08873-2

Abstract

Systemic contact dermatitis (SCD) is a generalized reactivation of type IV hypersensitivity skin diseases in individuals with previous sensitization after a contact allergen is administered systemically. Patients with SCD may consider their dermatitis unpredictable and recalcitrant since the causative allergens are difficult to find. If a patient has a pattern of dermatitis suggestive of SCD but fails to improve with conventional treatment, SCD should be taken into consideration. If doctors are not familiar with the presentations of SCD and the possible routes of allergen sensitization and exposure, the diagnosis of SCD may be delayed. In this work, we summarized all of the routes through which allergens can enter the body and cause SCD, including oral intake, local contact (through skin, inhalation, nasal spray and anal application), implants, and other iatrogenic or invasive routes (intravenous, intramuscular, intraarticular, and intravesicular). This will provide a comprehensive reference for the clinicians to identify the culprit of SCD.

© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords: Baboon syndrome; Iatrogenic; Implants; Inhalation; Oral intake; Systemic contact dermatitis

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