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Kiang JG, Smith JT, Anderson MN, et al. A novel therapy, using Ghrelin with pegylated G-CSF, inhibits brain hemorrhage from ionizing radiation or combined radiation injury. Pharm Pharmacol Int J. 2019;7(3):133-145doi: 10.15406/ppij.2019.07.00243.
Kiang, J. G., Smith, J. T., Anderson, M. N., Umali, M. V., Ho, C., Zhai, M., Lin, B., & Jiang, S. (2019). A novel therapy, using Ghrelin with pegylated G-CSF, inhibits brain hemorrhage from ionizing radiation or combined radiation injury. Pharmacy & pharmacology international journal, 7(3), 133-145. https://doi.org/10.15406/ppij.2019.07.00243
Kiang, J G, et al. "A novel therapy, using Ghrelin with pegylated G-CSF, inhibits brain hemorrhage from ionizing radiation or combined radiation injury." Pharmacy & pharmacology international journal vol. 7,3 (2019): 133-145. doi: https://doi.org/10.15406/ppij.2019.07.00243
Kiang JG, Smith JT, Anderson MN, Umali MV, Ho C, Zhai M, Lin B, Jiang S. A novel therapy, using Ghrelin with pegylated G-CSF, inhibits brain hemorrhage from ionizing radiation or combined radiation injury. Pharm Pharmacol Int J. 2019;7(3):133-145. doi: 10.15406/ppij.2019.07.00243. Epub 2019 Jun 26. PMID: 34368440; PMCID: PMC8341084.
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Pharm Pharmacol Int J. 2019;7(3):133-145. doi: 10.15406/ppij.2019.07.00243. Epub 2019 Jun 26.

A novel therapy, using Ghrelin with pegylated G-CSF, inhibits brain hemorrhage from ionizing radiation or combined radiation injury.

Pharmacy & pharmacology international journal

J G Kiang, J T Smith, M N Anderson, M V Umali, C Ho, M Zhai, B Lin, S Jiang

Affiliations

  1. Radiation Combined Injury Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, USA.
  2. Department of Medicine, Uniformed Services University of the Health Sciences, USA.
  3. Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, USA.
  4. Department of Biochemistry, University of California, USA.

PMID: 34368440 PMCID: PMC8341084 DOI: 10.15406/ppij.2019.07.00243

Abstract

Medical treatment becomes challenging when complicated injuries arise from secondary reactive metabolic and inflammatory products induced by initial acute ionizing radiation injury (RI) or when combined with subsequent trauma insult(s) (CI). With such detrimental effects on many organs, CI exacerbates the severity of primary injuries and decreases survival. Previously, in a novel study, we reported that ghrelin therapy significantly improved survival after CI. This study aimed to investigate whether brain hemorrhage induced by RI and CI could be inhibited by ghrelin therapy with pegylated G-CSF (i.e., Neulasta®, an FDA-approved drug). B6D2F1 female mice were exposed to 9.5 Gy

Keywords: AKT; ATP; Caspase-3; G-CSF; Ghrelin; MAPK; NRF; animal model; brain; hemorrhage; mdm2; mouse; p53; platelet; radiation; wound

Conflict of interest statement

Conflicts of interest Authors declare that there is no competing interest.

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