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Sabli IK, Sancho-Shimizu V. Inborn errors of autophagy and infectious diseases. Curr Opin Immunol. 2021;72:272-276doi: 10.1016/j.coi.2021.07.005.
Sabli, I. K., & Sancho-Shimizu, V. (2021). Inborn errors of autophagy and infectious diseases. Current opinion in immunology, 72272-276. https://doi.org/10.1016/j.coi.2021.07.005
Sabli, Ira Kd, and Sancho-Shimizu, Vanessa. "Inborn errors of autophagy and infectious diseases." Current opinion in immunology vol. 72 (2021): 272-276. doi: https://doi.org/10.1016/j.coi.2021.07.005
Sabli IK, Sancho-Shimizu V. Inborn errors of autophagy and infectious diseases. Curr Opin Immunol. 2021 Oct;72:272-276. doi: 10.1016/j.coi.2021.07.005. Epub 2021 Aug 07. PMID: 34371322.
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Curr Opin Immunol. 2021 Oct;72:272-276. doi: 10.1016/j.coi.2021.07.005. Epub 2021 Aug 07.

Inborn errors of autophagy and infectious diseases.

Current opinion in immunology

Ira Kd Sabli, Vanessa Sancho-Shimizu

Affiliations

  1. Dept of Paediatric Infectious Diseases & Virology, Imperial College London, London, UK; Centre for Paediatrics and Child Health, Faculty of Medicine, Imperial College London, London, UK.
  2. Dept of Paediatric Infectious Diseases & Virology, Imperial College London, London, UK; Centre for Paediatrics and Child Health, Faculty of Medicine, Imperial College London, London, UK. Electronic address: [email protected].

PMID: 34371322 DOI: 10.1016/j.coi.2021.07.005

Abstract

Autophagy is a fundamental component of cell-autonomous immunity, targeting intracellular pathogens including viruses and cytosolic bacteria to lysosomes for degradation. Genetic mutations in components of the autophagy pathway result in autoinflammatory and neurodegenerative disorders. We focus on recent developments through the newly discovered inborn errors of autophagy strictly predisposing to severe viral infections. These feature mutations in TBK1, ATG4A, MAP1LC3B2, and ATG7, leading to herpes encephalitis, recurrent lymphocytic meningitis, and paralytic poliomyelitis. We highlight how this enhances our understanding of autophagy mechanisms and its role in human viral disease. As we better understand the contribution of these genes to disease, we can aim to develop targeted therapies for enhanced infection control.

Copyright © 2021. Published by Elsevier Ltd.

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