J Bone Joint Surg Am. 2021 Nov 03;103(21):1970-1976. doi: 10.2106/JBJS.20.01345.
Cost Analysis of Volar Plate Fixation Versus Plaster Cast Immobilization for Intra-Articular Distal Radial Fractures.
The Journal of bone and joint surgery. American volume
C A Selles, M A M Mulders, S van Dieren, J C Goslings, N W L Schep,
Affiliations
Affiliations
- Trauma Unit, Department of Surgery, Amsterdam UMC, Location AMC, Amsterdam, the Netherlands.
- Department of Trauma and Hand Surgery, Maasstad Hospital, Rotterdam, the Netherlands.
- Department of Surgery, OLVG, Amsterdam, the Netherlands.
PMID: 34314400
DOI: 10.2106/JBJS.20.01345
Abstract
BACKGROUND: The aim of this study was to compare the cost-effectiveness and cost-utility between plaster cast immobilization and volar plate fixation for acceptably reduced intra-articular distal radial fractures.
METHODS: A cost-effectiveness analysis was conducted as part of a randomized controlled trial comparing operative (volar plate fixation) with nonoperative (plaster cast immobilization) treatment in patients between 18 and 75 years old with an acceptably reduced intra-articular distal radial fracture. Health-care utilization and use of resources per patient were documented prospectively and included direct medical costs, direct non-medical costs, and indirect costs. All analyses were performed according to the intention-to-treat principle.
RESULTS: The mean total cost per patient was $291 (95% bias-corrected and accelerated confidence interval [bcaCI] = -$1,286 to $1,572) higher in the operative group compared with the nonoperative group. The mean total number of quality-adjusted life-years (QALYs) gained at 12 months was significantly higher in the operative group than in the nonoperative group (mean difference = 0.15; 95% bcaCI = 0.056 to 0.243). The difference in the cost per QALY (incremental cost-effectiveness ratio [ICER]) was $2,008 (95% bcaCI = -$9,608 to $18,222) for the operative group compared with the nonoperative group, which means that operative treatment is more effective but also more expensive. Subgroup analysis including only patients with a paid job showed that the ICER was -$3,500 per QALY for the operative group with a paid job compared with the nonoperative group with a paid job, meaning that operative treatment is more effective and less expensive for patients with a paid job.
CONCLUSIONS: The difference in QALYs gained for the operatively treated group was equivalent to an additional 55 days of perfect health per year. In adult patients with an acceptably reduced intra-articular distal radial fracture, operative treatment is a cost-effective intervention, especially in patients with paid employment. Operative treatment is slightly more expensive than nonoperative treatment but provides better functional results and a better quality of life.
LEVEL OF EVIDENCE: Economic and Decision Analysis Level I. See Instructions for Authors for a complete description of levels of evidence.
Copyright © 2021 by The Journal of Bone and Joint Surgery, Incorporated.
Conflict of interest statement
Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJS/G640).
References
- Bentohami A, Bosma J, Akkersdijk GJ, van Dijkman B, Goslings JC, Schep NW. Incidence and characteristics of distal radial fractures in an urban population in The Netherlands. Eur J Trauma Emerg Surg. 2014 Jun;40(3):357-61. Epub 2014 Mar 27. - PubMed
- de Putter CE, Selles RW, Polinder S, Panneman MJ, Hovius SE, van Beeck EF. Economic impact of hand and wrist injuries: health-care costs and productivity costs in a population-based study. J Bone Joint Surg Am. 2012 May 2;94(9):e56. - PubMed
- Schneppendahl J, Windolf J, Kaufmann RA. Distal radius fractures: current concepts. J Hand Surg Am. 2012 Aug;37(8):1718-25. Epub 2012 Jul 3. - PubMed
- Mellstrand-Navarro C, Pettersson HJ, Tornqvist H, Ponzer S. The operative treatment of fractures of the distal radius is increasing: results from a nationwide Swedish study. Bone Joint J. 2014 Jul;96-B(7):963-9. - PubMed
- Mulders MAM, Walenkamp MMJ, van Dieren S, Goslings JC, Schep NWL; VIPER Trial Collaborators. Volar Plate Fixation Versus Plaster Immobilization in Acceptably Reduced Extra-Articular Distal Radial Fractures: A Multicenter Randomized Controlled Trial. J Bone Joint Surg Am. 2019 May 1;101(9):787-96. - PubMed
- Arora R, Lutz M, Deml C, Krappinger D, Haug L, Gabl M. A prospective randomized trial comparing nonoperative treatment with volar locking plate fixation for displaced and unstable distal radial fractures in patients sixty-five years of age and older. J Bone Joint Surg Am. 2011 Dec 7;93(23):2146-53. - PubMed
- Bartl C, Stengel D, Bruckner T, Gebhard F; ORCHID Study Group. The treatment of displaced intra-articular distal radius fractures in elderly patients. Dtsch Arztebl Int. 2014 Nov 14;111(46):779-87. - PubMed
- Rosberg HE, Carlsson KS, Dahlin LB. Prospective study of patients with injuries to the hand and forearm: costs, function, and general health. Scand J Plast Reconstr Surg Hand Surg. 2005;39(6):360-9. - PubMed
- Shauver MJ, Yin H, Banerjee M, Chung KC. Current and future national costs to Medicare for the treatment of distal radius fracture in the elderly. J Hand Surg Am. 2011 Aug;36(8):1282-7. Epub 2011 Jun 25. - PubMed
- Dutch Society for Surgery. Guideline Distal Radius Fractures, diagnosis and treatment. http://www.heelkunde.nl/uploads/h8/VM/h8VMOlRX83oW2NSR_5rTWw/Richtlijn_Distale_radius_fracturen_definitieve_versie_0511.pdf. Published 2010. Accessed November 1st, 2018, 2018. - PubMed
- Mulders MAM, Walenkamp MMJ, Goslings JC, Schep NWL. Internal plate fixation versus plaster in displaced complete articular distal radius fractures, a randomised controlled trial. BMC Musculoskelet Disord. 2016 Feb 9;17:68. - PubMed
- MacDermid JC, Turgeon T, Richards RS, Beadle M, Roth JH. Patient rating of wrist pain and disability: a reliable and valid measurement tool. J Orthop Trauma. 1998 Nov-Dec;12(8):577-86. - PubMed
- Vemer P, Rutten-van Mölken MP. Largely ignored: the impact of the threshold value for a QALY on the importance of a transferability factor. Eur J Health Econ. 2011 Oct;12(5):397-404. Epub 2010 May 30. - PubMed
- van Baal P, Perry-Duxbury M, Bakx P, Versteegh M, van Doorslaer E, Brouwer W. A cost-effectiveness threshold based on the marginal returns of cardiovascular hospital spending. Health Econ. 2019 Jan;28(1):87-100. Epub 2018 Oct 1. - PubMed
- Goossens ME, Rutten-van Mölken MP, Vlaeyen JW, van der Linden SM. The cost diary: a method to measure direct and indirect costs in cost-effectiveness research. J Clin Epidemiol. 2000 Jul;53(7):688-95. - PubMed
- Hakkaart-van Roijen L vdLN, Kouwmans C, Kanters T, Tan SS. Kostenhandleiding: Methodologie van kostenonderzoek en referentieprijzen voor economische evaluaties in de gezondheidszorg. Zorginstituut Nederland. 2015. Accessed 2021 May 27. https://www.zorginstituutnederland.nl/binaries/zinl/documenten/publicatie/2016/02/29/richtlijn-voor-het-uitvoeren-van-economische-evaluaties-in-de-gezondheidszorg/Richtlijn+voor+het+uitvoeren+van+economische+evaluaties+in+de+gezondheidszorg+%28verdiepingsmodules%29.pdf - PubMed
- Hakkaart-van Roijen L. Short Form – Health and Labour Questionnaire (SF-HLQ). In. Rotterdam: Institute for Medical Technology Assessment, Erasmus Medical Center; 2007. - PubMed
- van Roijen L, Essink-Bot ML, Koopmanschap MA, Bonsel G, Rutten FF. Labor and health status in economic evaluation of health care. The Health and Labor Questionnaire. Int J Technol Assess Health Care. 1996 Summer;12(3):405-15. - PubMed
- van den Hout WB. The value of productivity: human-capital versus friction-cost method. Ann Rheum Dis. 2010 Jan;69(Suppl 1):i89-91. - PubMed
- Barber JA, Thompson SG. Analysis of cost data in randomized trials: an application of the non-parametric bootstrap. Stat Med. 2000 Dec 15;19(23):3219-36. - PubMed
- Cohen DJ, Reynolds MR. Interpreting the results of cost-effectiveness studies. J Am Coll Cardiol. 2008 Dec 16;52(25):2119-26. - PubMed
- de Putter CE, Selles RW, Polinder S, Hartholt KA, Looman CW, Panneman MJ, Verhaar JA, Hovius SE, van Beeck EF. Epidemiology and health-care utilisation of wrist fractures in older adults in The Netherlands, 1997-2009. Injury. 2013 Apr;44(4):421-6. Epub 2012 Nov 27. - PubMed
- Levin SM, Nelson CO, Botts JD, Teplitz GA, Kwon Y, Serra-Hsu F. Biomechanical evaluation of volar locking plates for distal radius fractures. Hand (N Y). 2008 Mar;3(1):55-60. Epub 2007 Aug 7. - PubMed
- Mulders MAM, Walenkamp MMJ, van Dieren S, Goslings JC, Schep NWL; VIPER Trial Collaborators. Volar Plate Fixation in Adults with a Displaced Extra-Articular Distal Radial Fracture Is Cost-Effective. J Bone Joint Surg Am. 2020 Apr 1;102(7):609-16. - PubMed
- Swart E, Tulipan J, Rosenwasser MP. How Should the Treatment Costs of Distal Radius Fractures Be Measured? Am J Orthop (Belle Mead NJ). 2017 Jan/Feb;46(1):E54-9. - PubMed
- U.S. Centers for Medicare & Medicaid Services. Physician fee schedule. 2016. Accessed 2020 Nov 10. https://www.cms.gov/apps/physician-fee-schedule - PubMed
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