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Pillar S, Amer R. The association between vitamin D and uveitis: A comprehensive review. Surv Ophthalmol. 2021;doi: 10.1016/j.survophthal.2021.07.006.
Pillar, S., & Amer, R. (2021). The association between vitamin D and uveitis: A comprehensive review. Survey of ophthalmology, . https://doi.org/10.1016/j.survophthal.2021.07.006
Pillar, Shani, and Amer, Radgonde. "The association between vitamin D and uveitis: A comprehensive review." Survey of ophthalmology vol. (2021). doi: https://doi.org/10.1016/j.survophthal.2021.07.006
Pillar S, Amer R. The association between vitamin D and uveitis: A comprehensive review. Surv Ophthalmol. 2021 Jul 31; doi: 10.1016/j.survophthal.2021.07.006. Epub 2021 Jul 31. PMID: 34343538.
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Surv Ophthalmol. 2021 Jul 31; doi: 10.1016/j.survophthal.2021.07.006. Epub 2021 Jul 31.

The association between vitamin D and uveitis: A comprehensive review.

Survey of ophthalmology

Shani Pillar, Radgonde Amer

Affiliations

  1. Department of Ophthalmology, Hadassah Medical Organization, Hebrew University of Jerusalem, Israel. Electronic address: [email protected].
  2. Department of Ophthalmology, Hadassah Medical Organization, Hebrew University of Jerusalem, Israel.

PMID: 34343538 DOI: 10.1016/j.survophthal.2021.07.006

Abstract

Vitamin D plays an important role in both the innate and adaptive immune systems. We review published data on the relationship between uveitis and vitamin D levels or vitamin D-associated gene polymorphisms. A search of the PubMed and Medline databases was conducted to identify relevant articles concerning vitamin D and uveitis. Sixteen studies were included in this review, and the evidence they present, linking low vitamin D levels with uveitis, is compelling. The uveitic entities shown to be modulated by hypovitaminosis D include, but are not limited to, HLA-B27-associated acute anterior uveitis, Vogt-Koyanagi-Harada (VKH) disease, sarcoidosis-associated uveitis, and juvenile idiopathic arthritis-associated uveitis. Specific polymorphisms of vitamin D family genes were found to correlate with uveitis in ankylosing spondylitis, Behçet's disease, VKH, and HLA B27-positive patients. Further understanding of the role of vitamin D, a known regulator of inflammatory processes, in noninfectious uveitis may advance capabilities in the fields of disease prevention and treatment.

Copyright © 2021. Published by Elsevier Inc.

Keywords: Behçet disease; HLA-B27; Hypovitaminosis; Juvenile idiopathic arthritis; Ocular inflammation; Sarcoidosis; Uveitis; Vitamin D; Vogt-Koyanagi-Harada

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