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Dachy G, Pochet JM, Labriola L, et al. Severe hypercalcaemia early after kidney transplantation in two patients with severe secondary hyperparathyroidism previously treated with etelcalcetide. Clin Kidney J. 2021;14(8):1977-1979doi: 10.1093/ckj/sfab063.
Dachy, G., Pochet, J. M., Labriola, L., Buemi, A., Gillion, V., Jadoul, M., Kanaan, N., & Devresse, A. (2021). Severe hypercalcaemia early after kidney transplantation in two patients with severe secondary hyperparathyroidism previously treated with etelcalcetide. Clinical kidney journal, 14(8), 1977-1979. https://doi.org/10.1093/ckj/sfab063
Dachy, Guillaume, et al. "Severe hypercalcaemia early after kidney transplantation in two patients with severe secondary hyperparathyroidism previously treated with etelcalcetide." Clinical kidney journal vol. 14,8 (2021): 1977-1979. doi: https://doi.org/10.1093/ckj/sfab063
Dachy G, Pochet JM, Labriola L, Buemi A, Gillion V, Jadoul M, Kanaan N, Devresse A. Severe hypercalcaemia early after kidney transplantation in two patients with severe secondary hyperparathyroidism previously treated with etelcalcetide. Clin Kidney J. 2021 Mar 17;14(8):1977-1979. doi: 10.1093/ckj/sfab063. eCollection 2021 Aug. PMID: 34345422; PMCID: PMC8323146.
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Clin Kidney J. 2021 Mar 17;14(8):1977-1979. doi: 10.1093/ckj/sfab063. eCollection 2021 Aug.

Severe hypercalcaemia early after kidney transplantation in two patients with severe secondary hyperparathyroidism previously treated with etelcalcetide.

Clinical kidney journal

Guillaume Dachy, Jean-Michel Pochet, Laura Labriola, Antoine Buemi, Valentine Gillion, Michel Jadoul, Nada Kanaan, Arnaud Devresse

Affiliations

  1. Department of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  2. Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.
  3. Department of Abdominal Surgery and Transplantation, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

PMID: 34345422 PMCID: PMC8323146 DOI: 10.1093/ckj/sfab063

Abstract

Cinacalcet and, more recently, etelcalcetide revolutionized the treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney transplant (KT) usually improves CKD-MBD. However, a significant proportion of KT recipients have high serum calcium levels, not requiring any treatment. We report two patients previously treated with etelcalcetide who developed severe (>3.3 mmol/L) hypercalcaemia in the early post-KT course, requiring parathyroidectomy. Pathological studies showed parathyroid adenomas and hyperplasia. One patient had a graft biopsy showing numerous intratubular calcium phosphate crystals. These observations should prompt pharmacovigilance studies and careful follow-up of KT recipients previously treated with etelcalcetide.

© The Author(s) 2021. Published by Oxford University Press on behalf of ERA-EDTA.

Keywords: calcimimetics; etelcalcetide; haemodialysis; hypercalcaemia; kidney transplant; parathyroidectomy

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