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Choi S, Baudot M, Vivas O, et al. Slowing down as we age: aging of the cardiac pacemaker's neural control. Geroscience. 2021;doi: 10.1007/s11357-021-00420-3.
Choi, S., Baudot, M., Vivas, O., & Moreno, C. M. (2021). Slowing down as we age: aging of the cardiac pacemaker's neural control. GeroScience, . https://doi.org/10.1007/s11357-021-00420-3
Choi, Sabrina, et al. "Slowing down as we age: aging of the cardiac pacemaker's neural control." GeroScience vol. (2021). doi: https://doi.org/10.1007/s11357-021-00420-3
Choi S, Baudot M, Vivas O, Moreno CM. Slowing down as we age: aging of the cardiac pacemaker's neural control. Geroscience. 2021 Jul 22; doi: 10.1007/s11357-021-00420-3. Epub 2021 Jul 22. PMID: 34292477.
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Geroscience. 2021 Jul 22; doi: 10.1007/s11357-021-00420-3. Epub 2021 Jul 22.

Slowing down as we age: aging of the cardiac pacemaker's neural control.

GeroScience

Sabrina Choi, Matthias Baudot, Oscar Vivas, Claudia M Moreno

Affiliations

  1. Department of Physiology & Biophysics, University of Washington, Seattle, WA, 98195, USA.
  2. Department of Physiology & Biophysics, University of Washington, Seattle, WA, 98195, USA. [email protected].

PMID: 34292477 DOI: 10.1007/s11357-021-00420-3

Abstract

The cardiac pacemaker ignites and coordinates the contraction of the whole heart, uninterruptedly, throughout our entire life. Pacemaker rate is constantly tuned by the autonomous nervous system to maintain body homeostasis. Sympathetic and parasympathetic terminals act over the pacemaker cells as the accelerator and the brake pedals, increasing or reducing the firing rate of pacemaker cells to match physiological demands. Despite the remarkable reliability of this tissue, the pacemaker is not exempt from the detrimental effects of aging. Mammals experience a natural and continuous decrease in the pacemaker rate throughout the entire lifespan. Why the pacemaker rhythm slows with age is poorly understood. Neural control of the pacemaker is remodeled from birth to adulthood, with strong evidence of age-related dysfunction that leads to a downshift of the pacemaker. Such evidence includes remodeling of pacemaker tissue architecture, alterations in the innervation, changes in the sympathetic acceleration and the parasympathetic deceleration, and alterations in the responsiveness of pacemaker cells to adrenergic and cholinergic modulation. In this review, we revisit the main evidence on the neural control of the pacemaker at the tissue and cellular level and the effects of aging on shaping this neural control.

© 2021. The Author(s).

Keywords: Autonomic control; Cardiac aging; Cardiac pacemaker; Heart rate

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