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Kuhn B, Haap W, Obst-Sander U, et al. What We Learned in 25 Years of Interactive Molecular Design Sessions. ChemMedChem. 2021;16(18):2760-2763doi: 10.1002/cmdc.202100351.
Kuhn, B., Haap, W., Obst-Sander, U., Kramer, C., & Stahl, M. (2021). What We Learned in 25 Years of Interactive Molecular Design Sessions. ChemMedChem, 16(18), 2760-2763. https://doi.org/10.1002/cmdc.202100351
Kuhn, Bernd, et al. "What We Learned in 25 Years of Interactive Molecular Design Sessions." ChemMedChem vol. 16,18 (2021): 2760-2763. doi: https://doi.org/10.1002/cmdc.202100351
Kuhn B, Haap W, Obst-Sander U, Kramer C, Stahl M. What We Learned in 25 Years of Interactive Molecular Design Sessions. ChemMedChem. 2021 Sep 16;16(18):2760-2763. doi: 10.1002/cmdc.202100351. Epub 2021 Aug 10. PMID: 34374230.
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ChemMedChem. 2021 Sep 16;16(18):2760-2763. doi: 10.1002/cmdc.202100351. Epub 2021 Aug 10.

What We Learned in 25 Years of Interactive Molecular Design Sessions.

ChemMedChem

Bernd Kuhn, Wolfgang Haap, Ulrike Obst-Sander, Christian Kramer, Martin Stahl

Affiliations

  1. Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, 4070, Basel, Switzerland.

PMID: 34374230 DOI: 10.1002/cmdc.202100351

Abstract

We retrace Prof. François Diederich's consultancy work for Roche and its impact over the years he worked with us. François Diederich uniquely shaped our approach to molecular design, and interactions with him and his research group at ETH Zurich have created deep insights into molecular recognition. Herein we share how his style and approach continue to inspire us.

© 2021 Wiley-VCH GmbH.

Keywords: drug discovery; knowledge generation; molecular design; molecular recognition

References

  1. K. Müller, Chimia 2014, 68, 472-482. - PubMed
  2. M. Stahl, W. Guba, M. Kansy, Drug Discovery Today 2006, 11, 326-333. - PubMed
  3. P. R. Gerber, K. Müller, J. Comput.-Aided Mol. Des. 1995, 9, 251-268. - PubMed
  4. C. Oefner, A. Binggeli, V. Breu, D. Bur, J.-P. Clozel, A. D'Arcy, A. Dorn, W. Fischli, F. Grüninger, R. Güller, G. Hirth, H. Märki, S. Mathews, M. Müller, R. Ridley, H. Stadier, E. Vieira, M. Wilhelm, F. Winkler, W. Wostl, Chem. Biol. 1999, 6, 127-131. - PubMed
  5. D. A. Carcache, S. R. Hörtner, A. Bertogg, C. Binkert, D. Bur, H. P. Märki, A. Dorn, F. Diederich, ChemBioChem 2002, 3, 1137-1141. - PubMed
  6. M. Giroud, U. Dietzel, L. Anselm, D. Banner, A. Kuglstatter, J. Benz, J.-B. Blanc, D. Gaufreteau, H. Liu, X. Lin, A. Stich, B. Kuhn, F. Schuler, M. Kaiser, R. Brun, T. Schirmeister, C. Kisker, F. Diederich, W. Haap, J. Med. Chem. 2018, 61, 3350-3369. - PubMed
  7. M. Giroud, B. Kuhn, S. Saint-Auret, C. Kuratli, R. E. Martin, F. Schuler, F. Diederich, M. Kaiser, R. Brun, T. Schirmeister, W. Haap, J. Med. Chem. 2018, 61, 3370-3388. - PubMed
  8. Molecular Operating Environment (MOE), 2020.09; Chemical Computing Group ULC,1010 Sherbooke St. West, Suite #910, Montreal, QC, Canada, H3 A 2R7, 2021. - PubMed
  9. A. Biela, M. Betz, A. Heine, G. Klebe, ChemMedChem 2012, 7, 1423-1434. - PubMed
  10. K. A. Brameld, B. Kuhn, D. C. Reuter, M. Stahl, J. Chem. Inf. Model. 2008, 48, 1-24. - PubMed
  11. C. Schärfer, T. Schulz-Gasch, H.-C. Ehrlich, W. Guba, M. Rarey, M. Stahl, J. Med. Chem. 2013, 56, 2016-2028. - PubMed
  12. L. A. Hardegger, B. Kuhn, B. Spinnler, L. Anselm, R. Ecabert, M. Stihle, B. Gsell, R. Thoma, J. Diez, J. Benz, J.-M. Plancher, G. Hartmann, D. W. Banner, W. Haap, F. Diederich, Angew. Chem. Int. Ed. Engl. 2011, 50, 314-318. - PubMed
  13. L. A. Hardegger, B. Kuhn, B. Spinnler, L. Anselm, R. Ecabert, M. Stihle, B. Gsell, R. Thoma, J. Diez, J. Benz, J.-M. Plancher, G. Hartmann, Y. Isshiki, K. Morikami, N. Shimma, W. Haap, D. W. Banner, F. Diederich, ChemMedChem 2011, 6, 2048-2054. - PubMed
  14. M. Harder, B. Kuhn, F. Diederich, ChemMedChem 2013, 8, 397-404. - PubMed
  15. M. Giroud, J. Ivkovic, M. Martignoni, M. Fleuti, N. Trapp, W. Haap, A. Kuglstatter, J. Benz, B. Kuhn, T. Schirmeister, F. Diederich, ChemMedChem 2017, 12, 257-270. - PubMed
  16. K. Müller, C. Faeh, F. Diederich, Science 2007, 317, 1881-1886. - PubMed
  17. E. Schweizer, A. Hoffmann-Röder, K. Schärer, J. A. Olsen, C. Fäh, P. Seiler, U. Obst-Sander, B. Wagner, M. Kansy, F. Diederich, ChemMedChem 2006, 1, 611-621. - PubMed
  18. M. Morgenthaler, J. D. Aebi, F. Grüninger, D. Mona, B. Wagner, M. Kansy, F. Diederich, J. Fluorine Chem. 2008, 129, 852-865. - PubMed
  19. E. Persch, O. Dumele, F. Diederich, Angew. Chem. Int. Ed. 2015, 54, 3290-3327; - PubMed
  20. Angew. Chem. 2015, 127, 3341-3382. - PubMed
  21. S. Mecozzi, J. Rebek Jr, Chem. Eur. J. 1998, 4, 1016-1022. - PubMed
  22. M. Zürcher, F. Diederich, J. Org. Chem. 2008, 73, 4345-4361. - PubMed
  23. B. Kuhn, J. E. Fuchs, M. Reutlinger, M. Stahl, N. R. Taylor, J. Chem. Inf. Model. 2011, 51, 3180-3198. - PubMed
  24. B. S. Lauber, L. A. Hardegger, A. K. Asraful, B. A. Lund, O. Dumele, M. Harder, B. Kuhn, R. A. Engh, F. Diederich, Chem. Eur. J. 2016, 22, 211-221. - PubMed

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