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Elife. 2021 Aug 04;10. doi: 10.7554/eLife.71610.

How lung cancer cells change identity.

eLife

Mitchell S von Itzstein, Benjamin J Drapkin, John D Minna

Affiliations

  1. Department of Internal Medicine, Division of Hematology and Oncology, the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States.
  2. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, United States.

PMID: 34346867 PMCID: PMC8337071 DOI: 10.7554/eLife.71610

Abstract

Changes in MAPK signaling allow lung cancer cells to transition between lineages that respond differently to treatment.

© 2021, von Itzstein et al.

Keywords: ERK signaling; cancer biology; human; lineage switching; lineage transformation; lung cancer

Conflict of interest statement

Mv, BD, JM No competing interests declared

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