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Horiuchi M, Okazaki K, Asano K, et al. The influence of short-term high-altitude acclimatization on cerebral and leg tissue oxygenation post-orthostasis. Eur J Appl Physiol. 2021;121(11):3095-3102doi: 10.1007/s00421-021-04765-7.
Horiuchi, M., Okazaki, K., Asano, K., Friend, A. T., Rossetti, G. M. K., & Oliver, S. J. (2021). The influence of short-term high-altitude acclimatization on cerebral and leg tissue oxygenation post-orthostasis. European journal of applied physiology, 121(11), 3095-3102. https://doi.org/10.1007/s00421-021-04765-7
Horiuchi, Masahiro, et al. "The influence of short-term high-altitude acclimatization on cerebral and leg tissue oxygenation post-orthostasis." European journal of applied physiology vol. 121,11 (2021): 3095-3102. doi: https://doi.org/10.1007/s00421-021-04765-7
Horiuchi M, Okazaki K, Asano K, Friend AT, Rossetti GMK, Oliver SJ. The influence of short-term high-altitude acclimatization on cerebral and leg tissue oxygenation post-orthostasis. Eur J Appl Physiol. 2021 Nov;121(11):3095-3102. doi: 10.1007/s00421-021-04765-7. Epub 2021 Jul 28. PMID: 34319446.
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Eur J Appl Physiol. 2021 Nov;121(11):3095-3102. doi: 10.1007/s00421-021-04765-7. Epub 2021 Jul 28.

The influence of short-term high-altitude acclimatization on cerebral and leg tissue oxygenation post-orthostasis.

European journal of applied physiology

Masahiro Horiuchi, Kazunobu Okazaki, Katsumi Asano, Alexander T Friend, Gabriella M K Rossetti, Samuel J Oliver

Affiliations

  1. Division of Human Environmental Science, Mount Fuji Research Institute, Fuji-yoshida-city, Japan. [email protected].
  2. Research Center for Urban Health and Sports, Osaka City University, Osaka, Japan.
  3. Non-Profit Organization, Mount Fuji Research Station, Tokyo, Japan.
  4. School of Sport, Health and Exercise Sciences, Bangor University, Bangor, UK.
  5. Center for Integrative Neuroscience and Neurodynamics, University of Reading, Reading, UK.

PMID: 34319446 DOI: 10.1007/s00421-021-04765-7

Abstract

PURPOSE: Orthostasis at sea level decreases brain tissue oxygenation and increases risk of syncope. High altitude reduces brain and peripheral muscle tissue oxygenation. This study determined the effect of short-term altitude acclimatization on cerebral and peripheral leg tissue oxygenation index (TOI) post-orthostasis.

METHOD: Seven lowlanders completed a supine-to-stand maneuver at sea level (450 m) and for 3 consecutive days at high altitude (3776 m). Cardiorespiratory measurements and near-infrared spectroscopy-derived oxygenation of the frontal lobe (cerebral TOI) and vastus lateralis (leg TOI) were measured at supine and 5-min post-orthostasis.

RESULTS: After orthostasis at sea level, cerebral TOI decreased [mean Δ% (95% confidential interval): - 4.5%, (- 7.5, - 1.5), P < 0.001], whilst leg TOI was unchanged [- 4.6%, (- 10.9, 1.7), P = 0.42]. High altitude had no effect on cerebral TOI following orthostasis [days 1-3: - 2.3%, (- 5.3, 0.7); - 2.4%, (- 5.4, 0.6); - 2.1%, (- 5.1, 0.9), respectively, all P > 0.05], whereas leg TOI decreased [days 1-3: - 12.0%, (- 18.3, - 5.7); - 12.1%, (- 18.4, - 5.8); - 10.2%, (- 16.5, - 3.9), respectively, all P < 0.001]. This response did not differ with days spent at high altitude, despite evidence of cardiorespiratory acclimatization [increased peripheral oxygen saturation (supine: P = 0.01; stand: P = 0.02) and decreased end-tidal carbon dioxide (supine: P = 0.003; stand: P = 0.01)].

CONCLUSION: Cerebral oxygenation is preferentially maintained over leg oxygenation post-orthostasis at high altitude, suggesting different vascular regulation between cerebral and peripheral circulations. Short-term acclimatization to high altitude did not alter cerebral and leg oxygenation responses to orthostasis.

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords: Altitude; Blood pressure; Heart rate; Hypoperfusion; Hypoxia; Tissue oxygenation

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