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J Oral Maxillofac Pathol. 2021 Jan-Apr;25(1):204. doi: 10.4103/jomfp.JOMFP_212_20. Epub 2021 May 14.

Noncalcifying clear-cell variant of calcifying epithelial odontogenic tumor: A case report and review.

Journal of oral and maxillofacial pathology : JOMFP

Sangeeta Patankar, Sheetal Choudhari, Shubhra Sharma, Snehal Dhumal

Affiliations

  1. Department of Oral and Maxillofacial Pathology and Microbiology, YMT'S Dental College and PG Institute, Navi Mumbai, Maharashtra, India.

PMID: 34349445 PMCID: PMC8272472 DOI: 10.4103/jomfp.JOMFP_212_20

Abstract

Clear-cell tumors of the head and neck are biologically diverse consisting of benign, malignant and metastatic lesions. These tumors pose a diagnostic challenge. In the oral cavity, these may be derived from odontogenic/nonodontogenic epithelium or from mesenchyme or can be metastatic. Odontogenic tumors with clear-cell change are rare. Calcifying epithelial odontogenic tumor (CEOT) is a rare, benign, locally aggressive odontogenic epithelial tumor affecting the jaw. Here, we report a case of clear-cell variant of CEOT with its histopathological differential diagnosis. A 43-year-old male patient with swelling in his lower right back tooth region showed a well-defined radiolucent lesion with smooth corticated periphery on radiograph. On incisional biopsy, tumor showed small sheets, cords and islands of odontogenic epithelium with nests of clear cells with no evidence of calcification. A final diagnosis of CEOT was established by differentiating other odontogenic and nonodontogenic lesions on the basis of clinical, radiographic, histopathologic and special stain features.

Copyright: © 2021 Journal of Oral and Maxillofacial Pathology.

Keywords: Calcifying epithelial odontogenic tumor; Langerhans cells; clear cells; clear-cell tumor; noncalcifying clear-cell variant of calcifying epithelial odontogenic tumor; odontogenic tumor

Conflict of interest statement

There are no conflicts of interest.

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