Ugeskr Laeger. 2021 Aug 09;183(32).

[Circulating tumour DNA in the treatment of cancer].

Ugeskrift for laeger

[Article in Danish]
Cecilie Riis Iden, Amanda Frydendahl Boll Johansen, Nadia Øgaard, Iben Boutrup Kongsfelt, Kristian Egebjerg, Claus Lindbjerg Andersen, Morten Mau-Sørensen

PMID: 34378526

Abstract

Circulating tumour DNA analysis has a potential to improve multiple aspects of cancer management. This includes: a) early cancer detection in asymptomatic individuals, b) identification of patients with residual disease after curative intended treatment, c) patient stratification in relation to treatment decisions like adjuvant therapy and intensity of radiological surveillance, d) monitoring treatment effect for optimised adaptive therapy, e) identification of actionable targets, and f) early recurrence detection. These points are summarised in this review.

Substances

• Circulating Tumor DNA

MeSH terms

• Circulating Tumor DNA* / genetics
• Early Detection of Cancer
• Humans
• Neoplasms* / diagnosis
• Neoplasms* / drug therapy
• Neoplasms* / genetics

Publication Types

• Journal Article
• Review