Display options
Cite
Boni S, Marin GH, Campaña L, et al. Disparities in antimicrobial consumption and resistance within a country: the case of beta-lactams in Argentina. Rev Panam Salud Publica. 2021;45:e76doi: 10.26633/RPSP.2021.76.
Boni, S., Marin, G. H., Campaña, L., Marin, L., Corso, A., Risso-Patron, S., Gabriel, F., Garay, V., & Limeres, M. (2021). Disparities in antimicrobial consumption and resistance within a country: the case of beta-lactams in Argentina. Revista panamericana de salud publica = Pan American journal of public health, 45e76. https://doi.org/10.26633/RPSP.2021.76
Boni, Silvia, et al. "Disparities in antimicrobial consumption and resistance within a country: the case of beta-lactams in Argentina." Revista panamericana de salud publica = Pan American journal of public health vol. 45 (2021): e76. doi: https://doi.org/10.26633/RPSP.2021.76
Boni S, Marin GH, Campaña L, Marin L, Corso A, Risso-Patron S, Gabriel F, Garay V, Limeres M. Disparities in antimicrobial consumption and resistance within a country: the case of beta-lactams in Argentina. Rev Panam Salud Publica. 2021 Jul 26;45:e76. doi: 10.26633/RPSP.2021.76. eCollection 2021. PMID: 34322161; PMCID: PMC8312146.
Copy Download .nbib Format: NLM
Share it on

Rev Panam Salud Publica. 2021 Jul 26;45:e76. doi: 10.26633/RPSP.2021.76. eCollection 2021.

Disparities in antimicrobial consumption and resistance within a country: the case of beta-lactams in Argentina.

Revista panamericana de salud publica = Pan American journal of public health

Silvia Boni, Gustavo H Marin, Laura Campaña, Lupe Marin, Alejandra Corso, Soledad Risso-Patron, Fernanda Gabriel, Valeria Garay, Manuel Limeres

Affiliations

  1. National Administration of Drugs, Food and Technology Buenos Aires Argentina National Administration of Drugs, Food and Technology, Buenos Aires, Argentina.
  2. National University La Plata-CUFAR-CONICET La Plata Argentina National University La Plata-CUFAR-CONICET, La Plata, Argentina.
  3. Ministry of Health Buenos Aires Argentina Ministry of Health, Buenos Aires, Argentina.

PMID: 34322161 PMCID: PMC8312146 DOI: 10.26633/RPSP.2021.76

Abstract

OBJECTIVE: To describe bacterial resistance and antimicrobial consumption ratio at the subnational level in Argentina during 2018, considering beta-lactams group as a case-study.

METHODS: Antimicrobial consumption was expressed as defined daily doses (DDD)/1000 inhabitants. Resistance of

RESULTS: The most widely consumed beta-lactams in Argentina were amoxicillin (3.64) for the penicillin sub-group, cephalexin (0.786) for first generation cephalosporins, cefuroxime (0.022) for second generation; cefixime (0.043) for third generation and cefepime (0.0001) for the fourth generation group. Comparison between beta-lactams consumption and bacterial resistance demonstrated great disparities between the six regions of the country.

CONCLUSIONS: The case-study of Argentina shows that antimicrobial consumption and resistance of the most common pathogens differed among regions, reflecting different realities within the same country. Because this situation might also be occurring in other countries, this data should be taken into account to target local efforts towards better antimicrobial use, to improve antimicrobial stewardship programs and to propose more suitable sales strategies in order to prevent and control antimicrobial resistance.

Keywords: Argentina; Drug resistance, microbial; beta-lactams

References

  1. N Engl J Med. 2014 Nov 6;371(19):1761-3 - PubMed
  2. Rev Panam Salud Publica. 2011 Dec;30(6):519-28 - PubMed
  3. Angew Chem Int Ed Engl. 2016 Jun 1;55(23):6600-26 - PubMed
  4. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1152-6 - PubMed
  5. Rev Panam Salud Publica. 2011 Dec;30(6):619-26 - PubMed
  6. Nat Rev Microbiol. 2006 Jan;4(1):36-45 - PubMed
  7. Arch Intern Med. 2003 Apr 28;163(8):972-8 - PubMed
  8. Infect Control Hosp Epidemiol. 2019 Nov;40(11):1301-1304 - PubMed
  9. Emerg Infect Dis. 2002 Mar;8(3):278-82 - PubMed
  10. PLoS One. 2018 Jun 22;13(6):e0199436 - PubMed
  11. Front Microbiol. 2011 Nov 24;2:230 - PubMed
  12. Microbiol Mol Biol Rev. 2010 Sep;74(3):417-33 - PubMed
  13. Pathog Glob Health. 2015;109(7):309-18 - PubMed
  14. GMS Infect Dis. 2018 Aug 09;6:Doc05 - PubMed
  15. J Clin Diagn Res. 2015 Feb;9(2):DC08-12 - PubMed

Publication Types