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Tougaard RS, Laustsen C, Lassen TR, et al. Remodeling after myocardial infarction and effects of heart failure treatment investigated by hyperpolarized [1-. Magn Reson Med. 2021;87(1):57-69doi: 10.1002/mrm.28964.
Tougaard, R. S., Laustsen, C., Lassen, T. R., Qi, H., Lindhardt, J. L., Schroeder, M., Jespersen, N. R., Hansen, E. S. S., Ringgaard, S., Bøtker, H. E., Kim, W. Y., Stødkilde-Jørgensen, H., & Wiggers, H. (2022). Remodeling after myocardial infarction and effects of heart failure treatment investigated by hyperpolarized [1-. Magnetic resonance in medicine, 87(1), 57-69. https://doi.org/10.1002/mrm.28964
Tougaard, Rasmus Stilling, et al. "Remodeling after myocardial infarction and effects of heart failure treatment investigated by hyperpolarized [1-." Magnetic resonance in medicine vol. 87,1 (2022): 57-69. doi: https://doi.org/10.1002/mrm.28964
Tougaard RS, Laustsen C, Lassen TR, Qi H, Lindhardt JL, Schroeder M, Jespersen NR, Hansen ESS, Ringgaard S, Bøtker HE, Kim WY, Stødkilde-Jørgensen H, Wiggers H. Remodeling after myocardial infarction and effects of heart failure treatment investigated by hyperpolarized [1-. Magn Reson Med. 2022 Jan;87(1):57-69. doi: 10.1002/mrm.28964. Epub 2021 Aug 11. PMID: 34378800.
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Magn Reson Med. 2022 Jan;87(1):57-69. doi: 10.1002/mrm.28964. Epub 2021 Aug 11.

Remodeling after myocardial infarction and effects of heart failure treatment investigated by hyperpolarized [1-.

Magnetic resonance in medicine

Rasmus Stilling Tougaard, Christoffer Laustsen, Thomas Ravn Lassen, Haiyun Qi, Jakob Lykke Lindhardt, Marie Schroeder, Nichlas Riise Jespersen, Esben Søvsø Szocska Hansen, Steffen Ringgaard, Hans Erik Bøtker, Won Yong Kim, Hans Stødkilde-Jørgensen, Henrik Wiggers

Affiliations

  1. Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark.
  2. MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark.

PMID: 34378800 DOI: 10.1002/mrm.28964

Abstract

PURPOSE: Hyperpolarized [1-

METHODS: Thirty-five rats were scanned with hyperpolarized [1-

RESULTS: At 30 ± 0.5 days post MI, left ventricular ejection fraction (LVEF) differed between groups (sham, 77% ± 1%; placebo, 52% ± 3%; active, 63% ± 2%, P < .001). Cardiac metabolism, measured by both hyperpolarized [1-

CONCLUSION: In a rat model of moderate heart failure, medical treatment improved function, but did not on average influence [1-

© 2021 International Society for Magnetic Resonance in Medicine.

Keywords: MRS; animal models of human disease; heart failure; metabolism; myocardial infarction; remodeling

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