Display options
Cite
Xourgia X, Tsiouris S, Kolettis T, et al. Myocardial perfusion SPECT as a potential mediator on circulating chromogranin A in patients with old myocardial infarction. Hell J Nucl Med. 2021;24(2):114-121doi: 10.1967/s002449912351.
Xourgia, X., Tsiouris, S., Kolettis, T., Goudevenos, I., Arseniou, A., & Fotopoulos, A. D. (2021). Myocardial perfusion SPECT as a potential mediator on circulating chromogranin A in patients with old myocardial infarction. Hellenic journal of nuclear medicine, 24(2), 114-121. https://doi.org/10.1967/s002449912351
Xourgia, Xanthi, et al. "Myocardial perfusion SPECT as a potential mediator on circulating chromogranin A in patients with old myocardial infarction." Hellenic journal of nuclear medicine vol. 24,2 (2021): 114-121. doi: https://doi.org/10.1967/s002449912351
Xourgia X, Tsiouris S, Kolettis T, Goudevenos I, Arseniou A, Fotopoulos AD. Myocardial perfusion SPECT as a potential mediator on circulating chromogranin A in patients with old myocardial infarction. Hell J Nucl Med. 2021 May-Aug;24(2):114-121. doi: 10.1967/s002449912351. Epub 2021 Aug 06. PMID: 34352046.
Copy Download .nbib Format: NLM
Share it on

Hell J Nucl Med. 2021 May-Aug;24(2):114-121. doi: 10.1967/s002449912351. Epub 2021 Aug 06.

Myocardial perfusion SPECT as a potential mediator on circulating chromogranin A in patients with old myocardial infarction.

Hellenic journal of nuclear medicine

Xanthi Xourgia, Spyridon Tsiouris, Theofilos Kolettis, Ioannis Goudevenos, Angelos Arseniou, Andreas D Fotopoulos

Affiliations

  1. University Hospital of Ioannina, Nuclear Medicine Dept. Stavros Niarchos Avenue, Ioannina 455 00, Greece. [email protected].

PMID: 34352046 DOI: 10.1967/s002449912351

Abstract

OBJECTIVE: Chromogranin A (CgA) is a soluble polypeptide stored within and released from secretory granules of endocrine and other cell types (including cardiomyocytes); CgA appears to be a marker of the overall neuroendocrine activity. Increased levels of serum CgA have been found not only in patients with neuroendocrine neoplasms but also with other malignancies, hypertension, myocardial infarction, heart, or renal failure.

SUBJECTS AND METHODS: A population of 307 patients (202 males, 105 females) was enrolled. The study group consisted of 118 individuals (38.4%) with myocardial infarction more than one year old (MI group); the remaining 189 (61.6%) had no known heart disease (control group). All patients underwent myocardial perfusion scintigraphy (MPS) after blood withdrawal for serum CgA measurement. To test whether a possible effect of old infarction on serum CgA is mediated by MPS findings, we employed analysis of covariance for three distinct categories of left ventricular (LV) perfusion deficits as dichotomous predictors: (1) any-type deficits (abnormal MPS); (2) reversible deficits (ischemia); and (3) fixed deficits (scar).

RESULTS: In all three MPS conditions, the effect of age, gender, and LV ejection fraction (EFLV) on serum CgA was statistically significant: women exhibited higher CgA levels than men (P=0.008-0.023), whereas increasing age and decreasing EFLV were associated with increasing CgA (all P<0.001). Conversely, no statistically significant differences in mean CgA levels were found between MI patients and normal controls with either abnormal MPS, scar, or ischemia, or their degree and extent.

CONCLUSION: Although serum CgA is significantly associated with age, gender, and EFLV in patients with an old MI, no association was found between CgA levels and either old MI history or MPS findings. The verified involvement of circulating CgA in the acute/subacute phase of infarction appears to be blunted in infarctions older than a year.

Publication Types