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Kishida K, Iida T, Yamada T, et al. d-Allose is absorbed via sodium-dependent glucose cotransporter 1 (SGLT1) in the rat small intestine. Metabol Open. 2021;11:100112doi: 10.1016/j.metop.2021.100112.
Kishida, K., Iida, T., Yamada, T., & Toyoda, Y. (2021). d-Allose is absorbed via sodium-dependent glucose cotransporter 1 (SGLT1) in the rat small intestine. Metabolism open, 11100112. https://doi.org/10.1016/j.metop.2021.100112
Kishida, Kunihiro, et al. "d-Allose is absorbed via sodium-dependent glucose cotransporter 1 (SGLT1) in the rat small intestine." Metabolism open vol. 11 (2021): 100112. doi: https://doi.org/10.1016/j.metop.2021.100112
Kishida K, Iida T, Yamada T, Toyoda Y. d-Allose is absorbed via sodium-dependent glucose cotransporter 1 (SGLT1) in the rat small intestine. Metabol Open. 2021 Jul 22;11:100112. doi: 10.1016/j.metop.2021.100112. eCollection 2021 Sep. PMID: 34381987; PMCID: PMC8339219.
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Metabol Open. 2021 Jul 22;11:100112. doi: 10.1016/j.metop.2021.100112. eCollection 2021 Sep.

d-Allose is absorbed via sodium-dependent glucose cotransporter 1 (SGLT1) in the rat small intestine.

Metabolism open

Kunihiro Kishida, Tetsuo Iida, Takako Yamada, Yukiyasu Toyoda

Affiliations

  1. Department of Science and Technology on Food Safety, Kindai University, 930 Nishimitani, Kinokawa, Wakayama, 649-6493, Japan.
  2. Research and Development, Matsutani Chemical Industry Company, Limited, 5-3 Kita-Itami, Itami, Hyogo, 664-8508, Japan.
  3. Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya, Aichi, 468-8503, Japan.

PMID: 34381987 PMCID: PMC8339219 DOI: 10.1016/j.metop.2021.100112

Abstract

d-Allose is the C3 epimer of d-glucose and has been reported to have beneficial health effects. The transporter mediating intestinal transport of d-allose is unknown. We examined whether d-allose is absorbed via sodium-dependent glucose cotransporter 1 (SGLT1) as well as via glucose transporter type 5 (GLUT5) using rats. For examination of absorption via SGLT1, KGA-2727, an SGLT1-specific inhibitor, and d-allose were orally administered. KGA-2727 blocked the increase of plasma d-allose levels and suppressed them throughout the experiment (0-180 min), whereas without KGA-2727, the plasma d-allose levels peaked at around 60-90 min. For examination of absorption via GLUT5, rats were fed a high-fructose diet for 3weeks to increase the abundance and activity of GLUT5 in the small intestine. High-fructose diet-fed rats did not exhibit significant changes in the plasma d-allose levels compared to control rats fed a high-glucose diet. These results indicate that SGLT1 but not GLUT5 mediates the intestinal absorption of d-allose.

© 2021 The Authors.

Keywords: Intestinal absorption; SGLT1; d-Allose

Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: T. Iida and T. Yamada are employed by Matsutani Chemical Industry

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