Display options
Cite
Morrison CD, DuVall MA, Hill CM, et al. Leptin receptor signaling is required for intact hypoglycemic counterregulation: A study in male Zucker rats. J Diabetes Complications. 2021;35(10):107994doi: 10.1016/j.jdiacomp.2021.107994.
Morrison, C. D., DuVall, M. A., Hill, C. M., Spann, R. A., & McDougal, D. H. (2021). Leptin receptor signaling is required for intact hypoglycemic counterregulation: A study in male Zucker rats. Journal of diabetes and its complications, 35(10), 107994. https://doi.org/10.1016/j.jdiacomp.2021.107994
Morrison, Christopher D, et al. "Leptin receptor signaling is required for intact hypoglycemic counterregulation: A study in male Zucker rats." Journal of diabetes and its complications vol. 35,10 (2021): 107994. doi: https://doi.org/10.1016/j.jdiacomp.2021.107994
Morrison CD, DuVall MA, Hill CM, Spann RA, McDougal DH. Leptin receptor signaling is required for intact hypoglycemic counterregulation: A study in male Zucker rats. J Diabetes Complications. 2021 Oct;35(10):107994. doi: 10.1016/j.jdiacomp.2021.107994. Epub 2021 Jul 15. PMID: 34325985; PMCID: PMC8435018.
Copy Download .nbib Format: NLM
Share it on

J Diabetes Complications. 2021 Oct;35(10):107994. doi: 10.1016/j.jdiacomp.2021.107994. Epub 2021 Jul 15.

Leptin receptor signaling is required for intact hypoglycemic counterregulation: A study in male Zucker rats.

Journal of diabetes and its complications

Christopher D Morrison, Marina A DuVall, Cristal M Hill, Redin A Spann, David H McDougal

Affiliations

  1. Neurosignaling Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
  2. Neurobiology of Metabolic Dysfunction Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
  3. Neurobiology of Metabolic Dysfunction Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. Electronic address: [email protected].

PMID: 34325985 PMCID: PMC8435018 DOI: 10.1016/j.jdiacomp.2021.107994

Abstract

Hypoglycemia is a major barrier to clinical management of persons with diabetes. Emerging evidence supports a role for leptin in gating hypoglycemic counterregulation. This work demonstrates that male leptin receptor null, Zucker (fa/fa), rats display severe impairments in hypoglycemic counterregulation. Thus, augmenting leptin levels may have clinical utility for preventing hypoglycemia.

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: Diabetes; Hypoglycemia; Leptin; Leptin receptors; Zucker rats

References

  1. Drugs. 2013 Jun;73(9):989-97 - PubMed
  2. Int J Obes. 1986;10(2):147-58 - PubMed
  3. Am J Physiol. 1993 Feb;264(2 Pt 1):E149-55 - PubMed
  4. Endocrinology. 1995 Oct;136(10):4360-7 - PubMed
  5. Endocrine. 2019 Jun;64(3):500-511 - PubMed
  6. Diabetes. 2003 Jul;52(7):1749-55 - PubMed
  7. Biochim Biophys Acta. 2009 May;1792(5):401-8 - PubMed
  8. Curr Diabetes Rev. 2014 Mar;10(2):131-45 - PubMed
  9. Diabetes. 1993 Feb;42(2):263-72 - PubMed
  10. Endocrinology. 1990 Apr;126(4):1873-9 - PubMed
  11. Metab Syndr Relat Disord. 2012 Feb;10(1):26-31 - PubMed
  12. Auton Neurosci. 2021 Jul 16;235:102853 - PubMed
  13. Metabolism. 1989 Jun;38(6):530-6 - PubMed
  14. Dig Dis Sci. 2007 Nov;52(11):3066-9 - PubMed
  15. Int J Obes Relat Metab Disord. 2000 Aug;24(8):976-81 - PubMed
  16. J Investig Med. 2018 Mar;66(3):641-647 - PubMed
  17. Exp Biol Med (Maywood). 2002 Oct;227(9):701-8 - PubMed
  18. Am J Physiol Endocrinol Metab. 2015 Dec 15;309(12):E960-7 - PubMed
  19. Clin Endocrinol (Oxf). 2001 Nov;55(5):639-47 - PubMed
  20. Horm Metab Res. 1981 May;13(5):259-63 - PubMed

Publication Types

Grant support