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Lai F, Mercaldo N, Wang CM, et al. Association between Inflammatory Conditions and Alzheimer's Disease Age of Onset in Down Syndrome. J Clin Med. 2021;10(14)doi: 10.3390/jcm10143116.
Lai, F., Mercaldo, N., Wang, C. M., Hersch, G. G., & Rosas, H. D. (2021). Association between Inflammatory Conditions and Alzheimer's Disease Age of Onset in Down Syndrome. Journal of clinical medicine, 10(14), . https://doi.org/10.3390/jcm10143116
Lai, Florence, et al. "Association between Inflammatory Conditions and Alzheimer's Disease Age of Onset in Down Syndrome." Journal of clinical medicine vol. 10,14 (2021). doi: https://doi.org/10.3390/jcm10143116
Lai F, Mercaldo N, Wang CM, Hersch GG, Rosas HD. Association between Inflammatory Conditions and Alzheimer's Disease Age of Onset in Down Syndrome. J Clin Med. 2021 Jul 15;10(14). doi: 10.3390/jcm10143116. PMID: 34300282; PMCID: PMC8307987.
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J Clin Med. 2021 Jul 15;10(14). doi: 10.3390/jcm10143116.

Association between Inflammatory Conditions and Alzheimer's Disease Age of Onset in Down Syndrome.

Journal of clinical medicine

Florence Lai, Nathaniel Mercaldo, Cassandra M Wang, Giovi G Hersch, Herminia Diana Rosas

Affiliations

  1. Department of Neurology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
  2. Department of Radiology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Athinoula A. Martinos Center for Biomedical Imaging, 149 13th Street, Charlestown, MA 02129, USA.
  3. Harvard College, Harvard University, Cambridge, MA 02130, USA.
  4. College of Arts and Sciences, Boston University, Boston, MA 02215, USA.

PMID: 34300282 PMCID: PMC8307987 DOI: 10.3390/jcm10143116

Abstract

Adults with Down syndrome (DS) have an exceptionally high prevalence of Alzheimer disease (AD), with an earlier age of onset compared with the neurotypical population. In addition to beta amyloid, immunological processes involved in neuroinflammation and in peripheral inflammatory/autoimmune conditions are thought to play important roles in the pathophysiology of AD. Individuals with DS also have a high prevalence of autoimmune/inflammatory conditions which may contribute to an increased risk of early AD onset, but this has not been studied. Given the wide range in the age of AD onset in those with DS, we sought to evaluate the relationship between the presence of inflammatory conditions and the age of AD onset. We performed a retrospective study on 339 adults with DS, 125 who were cognitively stable (CS) and 214 with a diagnosis of AD. Data were available for six autoimmune conditions (alopecia, celiac disease, hypothyroidism, psoriasis, diabetes and vitamin B12 deficiency) and for one inflammatory condition, gout. Gout was associated with a significant delay in the age of AD onset by more than 2.5 years. Our data suggests that inflammatory conditions may play a role in the age of AD onset in DS. Further studies are warranted.

Keywords: Alzheimer’s disease; Down syndrome; inflammatory conditions; medical co-morbidities

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