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Fernández-Veledo S, Ceperuelo-Mallafré V, Vendrell J. Rethinking succinate: an unexpected hormone-like metabolite in energy homeostasis. Trends Endocrinol Metab. 2021;32(9):680-692doi: 10.1016/j.tem.2021.06.003.
Fernández-Veledo, S., Ceperuelo-Mallafré, V., & Vendrell, J. (2021). Rethinking succinate: an unexpected hormone-like metabolite in energy homeostasis. Trends in endocrinology and metabolism: TEM, 32(9), 680-692. https://doi.org/10.1016/j.tem.2021.06.003
Fernández-Veledo, Sonia, et al. "Rethinking succinate: an unexpected hormone-like metabolite in energy homeostasis." Trends in endocrinology and metabolism: TEM vol. 32,9 (2021): 680-692. doi: https://doi.org/10.1016/j.tem.2021.06.003
Fernández-Veledo S, Ceperuelo-Mallafré V, Vendrell J. Rethinking succinate: an unexpected hormone-like metabolite in energy homeostasis. Trends Endocrinol Metab. 2021 Sep;32(9):680-692. doi: 10.1016/j.tem.2021.06.003. Epub 2021 Jul 20. PMID: 34301438.
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Trends Endocrinol Metab. 2021 Sep;32(9):680-692. doi: 10.1016/j.tem.2021.06.003. Epub 2021 Jul 20.

Rethinking succinate: an unexpected hormone-like metabolite in energy homeostasis.

Trends in endocrinology and metabolism: TEM

Sonia Fernández-Veledo, Victòria Ceperuelo-Mallafré, Joan Vendrell

Affiliations

  1. Department of Endocrinology and Nutrition and Research Unit, University Hospital of Tarragona Joan XXIII, Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: [email protected].
  2. Department of Endocrinology and Nutrition and Research Unit, University Hospital of Tarragona Joan XXIII, Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine and Surgery, University Rovira I Virgili, Tarragona, Spain.

PMID: 34301438 DOI: 10.1016/j.tem.2021.06.003

Abstract

There has been an explosion of interest in the signaling capacity of energy metabolites. A prime example is the Krebs cycle substrate succinate, an archetypal respiratory substrate with functions beyond energy production as an intracellular and extracellular signaling molecule. Long associated with inflammation, emerging evidence supports a key role for succinate in metabolic processes relating to energy management. As the natural ligand for SUCNR1, a G protein-coupled receptor, succinate is akin to hormones and likely functions as a reporter of metabolism and stress. In this review, we reconcile new and old observations to outline a regulatory role for succinate in metabolic homeostasis. We highlight the importance of the succinate-SUCNR1 axis in metabolic diseases as an integrator of macrophage immune response, and we discuss new metabolic functions recently ascribed to succinate in specific tissues. Because circulating succinate has emerged as a promising biomarker in chronic metabolic diseases, a better understanding of the physiopathological role of the succinate-SUCNR1 axis in metabolism might open new avenues for clinical use in patients with obesity or diabetes.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: SUCNR1; energy metabolite; metabolic diseases; metabolic function; succinate

Conflict of interest statement

Declaration of interests The authors have no interests to declare.

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